Rotundatin, a new 9,10-didydrophenanthrene derivative from Dendrobium rotundatum
TL;DR: Rotundatin, a new 9,10-dihydrophenanthrene derivative was isolated from the orchid, Dendrobium rotundatum, which also afforded the known stilbenoids 2,7-Dihydroxy-3,4,6-trimethoxyphenanthrin this article, nudol, moscatin and batatasin-III.
About: This article is published in Phytochemistry.The article was published on 1992-09-01. It has received 35 citations till now. The article focuses on the topics: Derivative (chemistry).
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TL;DR: The history, chemistry, and pharmacology of different Dendrobium species are reviewed on the basis of the latest academic literatures found in Google Scholar, PubMed, Sciencedirect, Scopus, and SID.
Abstract: Dendrobium species, commonly known as “Shihu” or “Huangcao,” represents the second largest genus of Orchidaceae, which are used commonly as tonic herbs and healthy food in many Asian countries. The aim of this paper is to review the history, chemistry, and pharmacology of different Dendrobium species on the basis of the latest academic literatures found in Google Scholar, PubMed, Sciencedirect, Scopus, and SID.
115 citations
Journal Article•
TL;DR: The article reviews medicinally important orchids along with recent pharmacological investigations.
Abstract: Orchids are largest and most diverse group among angiosperms. They are cultivated for beautiful flowers. They are widely known their economic importance but less for medicinal value. Some plants like Dendrobium crumenative, Eulophia campestris, Orchis latifolia, Vanda roxburghii and Vanda tessellata have been documented for their medicinal value.. Phytochemically some orchids have been reported to contain alkaloids, triterpenoids, flavonoids and stilbenoids. Ashtavarga (group of eight medicinal plants) is vital part of Ayurvedic formulations like Chyvanprasha and four plants viz, Riddhi, Vriddhi, Jivaka and Rishbhaka have been discussed as possible members of family Orchidaceae. Recently there has been tremendous progress in medicinal plants research; however orchids have not been exploited fully for their medicinal application. The article reviews medicinally important orchids along with recent pharmacological investigations.
70 citations
Book•
01 Jan 2011
TL;DR: In this article, the authors highlight the major breakthroughs in the history of the field and focus on future directions in the discovery and application of herb-derived medicines using reverse pharmacology.
Abstract: Bridging the gap between the ancient art of herbalism and the emerging sciences of ethnopharmocology and phytopharmacotherapy, this book highlights the major breakthroughs in the history of the field and focuses on future directions in the discovery and application of herb-derived medicines. Implementing the concept of reverse pharmacology, it inte
69 citations
TL;DR: A methanol extract from Dendrobium nobile showed a suppressive effect on umu gene expression of the SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen 2-(2-furyl)-3-(5-nitro-2)-acrylamide (furylfuramide) as discussed by the authors.
Abstract: A methanol extract from Dendrobium nobile showed a suppressive effect on umu gene expression of the SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (furylfuramide). The methanol extract from D. nobile was re-extracted with n-hexane, dichloromethane, 1-butanol, and water, respectively. A suppressive compound in the n-hexane extract fraction was isolated by SiO2 column chromatography and chemical fractionation and was identified as gigantol by EI-MS and 1H and 13C NMR spectroscopy. Gigantol suppressed the SOS-inducing activity of furylfuramide in the umu test. Gene expression was suppressed 90% at <0.73 μmol/mL, and the ID50 value was 0.35 μmol/mL. Gigantol was also assayed with the mutagen 3-amino-1,4-dimethyl-5H-pyrido[4,3b]indole (Trp-P-1), which requires liver metabolizing enzymes, and it suppressed the SOS-inducing activity of Trp-P-1 in the umu test. Gene expression was suppressed 91% at <0.73 μmol/mL, and the ID50 value was 0.32 μmol...
61 citations
TL;DR: In this article, a bibenzyl compound that possesses antimutagenic activity was isolated from the storage stem of Dendrobium nobile and used to suppress the expression of the umu gene following the induction of SOS response in Salmonella typhimurium TA1535/pSK1002.
Abstract: A bibenzyl compound that possesses antimutagenic activity was isolated from the storage stem of Dendrobium nobile. The isolated compound suppressed the expression of the umu gene following the induction of SOS response in Salmonella typhimurium TA1535/pSK1002 that have been treated with various mutagens. The suppressive compound was mainly localized in the n-hexane extract fraction of the processed D. nobile. This n-hexane fraction was further fractionated by silica gel column chromatography, which resulted in the purification and subsequent identification of the suppressive compound. EI-MS and (1)H and (13)C NMR spectroscopy were then used to delineate the structure of the compound that confers the observed antimutagenic activity. Comparison of the obtained spectrum with that found in the literature indicated that moscatilin is the secondary suppressive compound. When using 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (furylfuramide) as the mutagen, moscatilin suppressed 85% of the umu gene expression compared to the controls at <0.73 micromol/mL, with an ID(50) value of 0.41 micromol/mL. Additionally, moscatilin was tested for its ability to suppress the mutagenic activity of other well-known mutagens such as 4-nitroquinoline-1-oxide (4NQO), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), UV irradiation, 3-amino-1,4-dimethyl-5H-pyrido[4,3b]indole (Trp-P-1), benzo[a]pyrene (B[a]P), and aflatoxin B(1) (AFB(1)). With all of the aforementioned chemicals or treatments, moscatilin showed a dramatic reduction in their mutagenic potential. Interestingly, moscatilin almost completely suppressed (97%) the AFB(1)-induced SOS response at concentrations <0.73 micromol/mL, with an ID(50) of 0.08 micromol/mL. Finally, the antimutagenic activities of moscatilin against furylfuramide and Trp-P-1 were assayed by the Ames test using the S. typhimurium TA100 strain. The results those experiments indicated that moscatilin demonstrated a dramatic suppression of the mutagenicity of only Trp-P-1 but not furylfuramide.
60 citations
References
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TL;DR: An amorphous phenanthrene, named nudol has been isolated from Eulophia nuda, Eria carinata and E. stricta and was identified as 2,7-dihydroxy-3,4-dimethoxyphenanthrene.
74 citations
TL;DR: Batatasin, which occurs in dormant bulbils of yams and induces dormancy in this organ has been shown by spectrometric analysis and synthesis to be 3,3′-dihydroxy-5-methoxy-bibenzyl.
52 citations
TL;DR: Bulbophyllanthrin, a novel phenanthrene derivative from the orchid B. leopardium, was shown to have the structure 1a mainly on the basis of spectral evidence including 13 C and 2D NMR spectra as discussed by the authors.
43 citations
TL;DR: Aus Knollen von Loroglossum hircinum (L.) Rich, welche mit dem Pilz Rhizoctonia versicolor Muller et Nuesch infiziert worden sind, wird das fungistatisch wirksame Hircinol, C15H14O3, in Ausbeuten von 250-400 mg pro kg Knollengewebe isoliert as mentioned in this paper.
Abstract: Aus Knollen von Loroglossum hircinum (L.) Rich., welche mit dem Pilz Rhizoctonia versicolor Muller et Nuesch infiziert worden sind, wird das fungistatisch wirksame Hircinol, C15H14O3, in Ausbeuten von 250–400 mg pro kg Knollengewebe isoliert. Die Knollen enthalten ferner pro kg ca. 150 mg einer fungistatisch unwirksamen Substanz A. Beide Verbindungen scheinen dem Orchinol, einem aus Orchis militaris L. isolierten Pilzabwerhrstoff, chemisch nahe zu stehen. Substanz A hat sich als identisch mit dem von Hardegger und Mitarb. beschirebene Loroglossol erwiesen.
25 citations
TL;DR: Cirhopetalanthridin and cirrhopetalidinin, two new stilbenoids isolated from the orchid Cirrus andersonii, were shown to be 4,7-dihydroxy-2,3-methylenedioxy-9,10-dhydrophenanthrene and 3,2′-Dihydrox-5′methoxy-4,5-methylenioxy bibenzyl, respectively, from spectral and chemical evidence as mentioned in this paper.
25 citations