rrndb: the Ribosomal RNA Operon Copy Number Database
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Cites background from "rrndb: the Ribosomal RNA Operon Cop..."
...There are a number of reasons for this: DNA extraction bias may alter the estimated abundances of certain groups (16), heterogeneity in ribosomal operon number (11, 30) may affect relative estimates of group abundances, and the tested qPCR assays do not necessarily amplify rRNA genes belonging to all members of each targeted group....
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References
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"rrndb: the Ribosomal RNA Operon Cop..." refers methods in this paper
...Molecular methods for microbial diversity assessment rely primarily on PCR-amplification of 16S rRNA genes from complex samples followed by (i) cloning and sequencing of unique amplicons, (ii) separation of amplicons based on chemical composition via denaturing- or temperature-gradient gel electrophoresis (10,11), or (iii) separation of amplicons after restriction digestion based on size via terminal restriction fragment length polymorphism analysis (12)....
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"rrndb: the Ribosomal RNA Operon Cop..." refers background in this paper
...Microbes are the most abundant and most diverse forms of life on earth (1)....
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2,383 citations
"rrndb: the Ribosomal RNA Operon Cop..." refers methods in this paper
...Molecular methods for microbial diversity assessment rely primarily on PCR-amplification of 16S rRNA genes from complex samples followed by (i) cloning and sequencing of unique amplicons, (ii) separation of amplicons based on chemical composition via denaturing- or temperature-gradient gel electrophoresis (10,11), or (iii) separation of amplicons after restriction digestion based on size via terminal restriction fragment length polymorphism analysis (12)....
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2,181 citations