RUCAM in drug and herb induced liver injury: The update
Citations
504 citations
Cites background from "RUCAM in drug and herb induced live..."
...A crucial prerequisite is proper reporting of suspected DILI cases to regulatory agencies, capturing information on time to onset, clinical course, risk factors, concomitant drugs, relevant medical history, and response to re-administration.(63,374,375) Hy’s law cases should be reported to the agencies as a serious adverse event even in the postmarketing setting, and before completion of follow-up assessments....
[...]
327 citations
298 citations
185 citations
185 citations
Cites background from "RUCAM in drug and herb induced live..."
...Most clinicians diagnose DILI based on previous knowledge of a drug, temporal relationship and by ruling out other causes of liver injury which is applicable to patient safety [180]....
[...]
References
9,840 citations
"RUCAM in drug and herb induced live..." refers background or methods in this paper
...The use of the liver unspecific Naranjo scale [56] in suspected DILI and HILI cases is problematic [4,53,60–65,76] as criteria of hepatotoxicity and reexposure conditions, specific time to onset, criteria for recovery time, and critical diagnoses to exclude are not even unconsidered (Table 6) [53]....
[...]
...[56], for the WHO from the WHO database [57], and for the ad-hoc approach from Kaplowitz [58]....
[...]
...Since these items are irrelevant for DILI and HILI, they have less sensitivity for rare and idiosyncratic reactions prevalent in liver injury [53,56]....
[...]
...Among these liver unspecific methods is the Naranjo scale [56], the WHO global introspection method, WHO method in short [57], the ad hoc approach [58], and the KL method named after Karch and Lasagna [59]....
[...]
1,415 citations
"RUCAM in drug and herb induced live..." refers methods in this paper
...In this disease category belongs as examples not only the autoimmune hepatitis (AIH) that is well diagnosed by a specific score [52] and relapse while the suspected product has been discontinued, but also DILI and HILI that were validly diagnosed by the scoring causality method of the original RUCAM [8,9] and can now better be diagnosed with the updated RUCAM (Tables 2 and 3)....
[...]
1,291 citations
"RUCAM in drug and herb induced live..." refers background or methods in this paper
...Summing up the points of the criteria gives an overall assessment score that reflects the likelihood that the hepatic injury is due to a specific medication [8]....
[...]
...Establishing RUCAM with all core items and specific details was time-consuming and required some years as RUCAM was the first liver-specific causality CAM for DILI ever published worldwide [8,9]....
[...]
...This was originally named RUCAM (Roussel Uclaf Causality Assessment Method) [8,9] or later also synonymously CIOMS (Council for International Organizations of Medical Sciences) [33–36]....
[...]
...Those who then applied this final scal [8,9] called it eith r RUCAM or CIOMS in their publications [33–36]....
[...]
...In the majority of the DILI and HILI cases, injury is the result of an idiosyncratic reaction at recommended doses [8,14,18]....
[...]
1,055 citations
"RUCAM in drug and herb induced live..." refers background or methods in this paper
...Published in 1988, the first pragmatic hepatotoxicity CAM based on the qualitative French CAM with chronological and clinical criteria was designed specifically for liver injury cases by considering some characteristic features [39] and formed a sophisticated basis for subsequent algorithms [8,9,40]....
[...]
...Preceding versions were extended, specified, and quantified, while additional criteria have been introduced and weights attributed [39,40]....
[...]
...Its previous alternative name of CIOMS (Council for International Organizations of Medical Sciences) ascribed by some authors applying RUCAM goes back to the fact that the consensus meeting in Paris in 1989 was held under the auspices of the Council for International Organizations of Medical Sciences (CIOMS), directed at establishing definitions and uniform criteria for DILI [40]....
[...]
...Its previous alternative name of CIOMS (Council for International Organizations of Medical Sciences) ascribed by some authors applying RUCAM goes back to the fact that the consensus meeting in Paris in 1989 was held under the auspices of the Council for International Organizations of Medical Sciences (CIO S), directed at establishing definitions and uniform criteri for DILI [40]....
[...]
...The respective criteria were based on the conclusions of International Consensus Meetings in 1988 [39] and 1990 [40], as reviewed previously [8,9] and recently [14,48,49]....
[...]
949 citations
"RUCAM in drug and herb induced live..." refers background or methods in this paper
...RUCAM has been used to identify DILI and HILI events in case studies of prescription drugs [8,9,112,172], herbal medications [14,168], regulatory evaluations [81,86–88,90,92,94], epidemiological studies [2,99,113,173], genotyping studies [83,100], phase I clinical studies [154] and long-term post marketing clinical trials [5,102,158], just to name a few examples....
[...]
...DILI Flucloxacillin UK, other countries DILIGEN Study & International SAE Consortium 2009 Daly [83]...
[...]