Running as a Key Lifestyle Medicine for Longevity
TL;DR: This review details the findings surrounding the impact of running on various health outcomes and premature mortality, highlights plausible underlying mechanisms linking running with chronic disease prevention and longevity, identifies the estimated additional life expectancy among runners and other active individuals, and discusses whether there is adequate evidence to suggest that longevity benefits are attenuated with higher doses of running.
About: This article is published in Progress in Cardiovascular Diseases.The article was published on 2017-07-01 and is currently open access. It has received 214 citations till now. The article focuses on the topics: Longevity & Life expectancy.
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TL;DR: It is suggested that ageing research is entering a new era that has unique medical, commercial and societal implications, and that this era marks an inflection point in ageing research and for all biological research that affects the human healthspan.
Abstract: For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific credibility through the identification of gene variants that extend the lifespan of multicellular model organisms. Here we summarize the milestones that mark this scientific triumph, discuss different ageing pathways and processes, and suggest that ageing research is entering a new era that has unique medical, commercial and societal implications. We argue that this era marks an inflection point, not only in ageing research but also for all biological research that affects the human healthspan. The milestones that mark the advances in ageing research, the medical, commercial and societal implications of ageing and the different ageing pathways and processes that are associated with ageing are discussed.
581 citations
TL;DR: The authors focus on "healthy PA" with the emphasis on the pathophysiological effects of physical inactivity and PA on the cardiovascular system, mechanistic/triggering factors, the role of preventive actions through personal, education/environment, and societal/authoritative factors, as well as factors to provide guidance for caregivers of health promotion regarding PA.
332 citations
TL;DR: This review summarizes the current knowledge on biological age biomarkers, factors influencing biological aging, and antiaging interventions, with a focus on vascular aspects of the aging process and its cardiovascular disease related manifestations.
176 citations
TL;DR: This review will summarize recent efforts that have made significant strides in the application of novel analytic techniques to increase the predictive utility of CRF and understanding the potential harms associated with extreme volumes of PA.
139 citations
TL;DR: This systematic review synthesizes biomechanical risk factors related to the development of RRIs in non-injured runners to determine whether modification of these variables may assist in running injury prevention and management.
Abstract: Running is a popular form of physical activity with many health benefits. However, the incidence and prevalence of running-related injuries (RRIs) is high. Biomechanical factors may be related to the development of RRIs. This systematic review synthesizes biomechanical risk factors related to the development of RRIs in non-injured runners. PubMed, Web of Science, CINAHL, Embase, and SPORTDiscus were searched in July 2018 for original peer-reviewed prospective studies evaluating potential biomechanical factors associated with the development of RRIs. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Two reviewers independently assessed articles for inclusion and methodological quality. Due to methodological heterogeneity across studies, a narrative synthesis of findings was conducted, rather than a meta-analysis. Sixteen studies, including 13 of high quality and three of moderate quality, were included. A large number of biomechanical variables were evaluated, producing inconsistent evidence overall. Limited evidence indicated greater peak hip adduction in female runners developing patellofemoral pain and iliotibial band syndrome, but not for a mixed-sex population of cross-country runners sustaining an RRI. The relationship between vertical loading rate and RRIs was inconsistent. Other kinematic, kinetic and spatiotemporal factors were only studied to a limited extent. Current prospective evidence relating biomechanical variables to RRI risk is sparse and inconsistent, with findings largely dependent on the population and injuries being studied. Future research is needed to confirm these biomechanical risk factors and determine whether modification of these variables may assist in running injury prevention and management.
129 citations
References
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TL;DR: Objective and subjective measures of physical activity give qualitatively similar results regarding gender and age patterns of activity, however, adherence to physical activity recommendations according to accelerometer-measured activity is substantially lower than according to self-report.
Abstract: Purpose:To describe physical activity levels of children (6-11 yr), adolescents (12-19 yr), and adults (20+ yr), using objective data obtained with accelerometers from a representative sample of the U.S. population.Methods:These results were obtained from the 2003-2004 National Health and Nu
6,762 citations
"Running as a Key Lifestyle Medicine..." refers background in this paper
...This estimate drops dramatically, to 5%–10%, using PA data collected via objective measures.(9,10) Running is among the most popular types of exercise and PA in individuals who do engage in vigorous-intensity PA....
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TL;DR: In this article, the authors quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level.
6,119 citations
TL;DR: The 2011 Compendium is an update of a system for quantifying the energy cost of adult human PA and is a living document that is moving in the direction of being 100% evidence based.
Abstract: Purpose:The Compendium of Physical Activities was developed to enhance the comparability of results across studies using self-report physical activity (PA) and is used to quantify the energy cost of a wide variety of PA. We provide the second update of the Compendium, called the 2011 Compend
4,712 citations
01 Jan 2012
TL;DR: In this article, the authors quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level.
Abstract: Summary Background Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases such as coronary heart disease, type 2 diabetes, and breast and colon cancers, and shortens life expectancy. Because much of the world's population is inactive, this link presents a major public health issue. We aimed to quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level. Methods For our analysis of burden of disease, we calculated population attributable fractions (PAFs) associated with physical inactivity using conservative assumptions for each of the major non-communicable diseases, by country, to estimate how much disease could be averted if physical inactivity were eliminated. We used life-table analysis to estimate gains in life expectancy of the population. Findings Worldwide, we estimate that physical inactivity causes 6% (ranging from 3·2% in southeast Asia to 7·8% in the eastern Mediterranean region) of the burden of disease from coronary heart disease, 7% (3·9–9·6) of type 2 diabetes, 10% (5·6–14·1) of breast cancer, and 10% (5·7–13·8) of colon cancer. Inactivity causes 9% (range 5·1–12·5) of premature mortality, or more than 5·3 million of the 57 million deaths that occurred worldwide in 2008. If inactivity were not eliminated, but decreased instead by 10% or 25%, more than 533 000 and more than 1·3 million deaths, respectively, could be averted every year. We estimated that elimination of physical inactivity would increase the life expectancy of the world's population by 0·68 (range 0·41–0·95) years. Interpretation Physical inactivity has a major health effect worldwide. Decrease in or removal of this unhealthy behaviour could improve health substantially. Funding None.
4,616 citations
TL;DR: Benefits of a range of volumes of physical activity in a Taiwanese population between 1996 and 2008 were applicable to all age groups and both sexes, and to those with cardiovascular disease risks.
1,557 citations
"Running as a Key Lifestyle Medicine..." refers background in this paper
...individuals and should not obviate the observation that running andother PAevenbelow the currentminimumPAguidelines can significantly reduce premature mortality.(16,17,46,47,64)...
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...7 years longer for women in those who performed ≥150 min/wk of moderateintensity PA compared with inactive individuals without statistical adjustment for confounders.(46) At age 60, the extended life expectancy among active adults was 3....
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