Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial
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Additional excerpts
...The first clinical trial using a P. falciparum genetically attenuated parasite (GAP), lacking two genes p52 /p36 , led to a breakthrough infection (Spring et al., 2013)....
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182 citations
Cites background or methods from "Safety and efficacy of PfSPZ Vaccin..."
...falciparum infection by time-to-event analysis, and 29% efficacy by proportional analysis over a 6-month period.(56) Multiple studies of PfSPZ Vaccine are ongoing in both children and adults to optimize dose and regimen, including a large Phase 3 trial planned for Bioko Island in Equatorial Guinea....
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...In malaria-endemic areas, similar dosing in malaria-experienced adults provides more modest protection against CHMI(55) and naturallyoccurring malaria.(56) Recent testing in malaria-experienced, African adults who received five doses of 2....
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Cites background from "Safety and efficacy of PfSPZ Vaccin..."
...Previous malaria exposure may hamper the induction of vaccine responses, evidenced by the variation in the vaccine efficacy of RTS,S among populations with different intensities of malaria exposure (4), and the reduced immunogenicity and efficacy of PfSPZ vaccines in malaria exposed populations (14, 15)....
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...7 × 105 spz, 5 doses 18–35 years, Mali (n = 41) First blood smear positive, 0–24 weeks: 29 (14)...
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References
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