Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study
Francesco Landi,Alfonso J. Cruz-Jentoft,Rosa Liperoti,Andrea Russo,Silvia Giovannini,Matteo Tosato,Ettore Capoluongo,Roberto Bernabei,Graziano Onder +8 more
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TLDR
The results obtained from a representative sample of very old and frail subjects show that sarcopenia is associated with mortality, independently of age and other clinical and functional variables.Abstract:
Background and aims: sarcopenia has been indicated as a reliable marker of frailty and poor prognosis among the oldest individuals. We evaluated the impact of sarcopenia on the risk of all-cause death in a population of frail older persons living in community. Methods: we analysed data from the Aging and Longevity Study, a prospective cohort study that collected data on all subjects aged 80 years and older residing in the Sirente geographic area (n= 364). The present analysis was conducted among those subjects who were between 80 and 85 years of age at the time of the baseline assessment (n= 197). The main outcome measure was all-cause mortality over 7-year follow-up. According to the European Working Group on Sarcopenia in Older People (EWGSOP) criteria, the diagnosis of sarcopenia required the documentation of low muscle mass and the documentation of either low muscle strength or low physical performance. Cox proportional regression models were used to estimate crude and adjusted hazard ratios and 95% confidence intervals of death by the presence of sarcopenia. Results: using the EWGSOP-suggested criteria, 43 subjects with sarcopenia (21.8%) were identified. During the 7-year follow-up, 29 (67.4%) participants died among subjects with sarcopenia compared with 63 subjects (41.2%) without sarcopenia (P< 0.001). After adjusting for potential confounders including age, gender, education, activities of daily living (ADL) impairment, body mass index, hypertension, congestive heart failure, chronic obstructive pulmonary disease, number of diseases, TNF-α, participants with sarcopenia had a higher risk of death for all causes compared with non-sarcopenic subjects (HR: 2.32, 95% CI: 1.01–5.43). Conclusions: our results obtained from a representative sample of very old and frail subjects show that sarcopenia is associated with mortality, independently of age and other clinical and functional variables.read more
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Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group
Juergen M. Bauer,Gianni Biolo,Tommy Cederholm,Matteo Cesari,Alfonso J. Cruz-Jentoft,John E. Morley,Stuart M. Phillips,Cornel C. Sieber,Peter Stehle,Daniel Teta,Renuka Visvanathan,Elena Volpi,Yves Boirie +12 more
TL;DR: To help older people (>65 years) maintain and regain lean body mass and function, the PROT-AGE study group recommends average daily intake at least in the range of 1.2 g protein per kilogram of body weight per day.
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Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)
Alfonso J. Cruz-Jentoft,Francesco Landi,Stéphane M. Schneider,Clemente Zúñiga,Hidenori Arai,Yves Boirie,Liang Kung Chen,Roger A. Fielding,Finbarr C. Martin,Jean-Pierre Michel,Cornel C. Sieber,Jeffrey R. Stout,Stephanie A. Studenski,Bruno Vellas,Jean Woo,Mauro Zamboni,Tommy Cederholm +16 more
TL;DR: Prevalence of sarcopenia is substantial in most geriatric settings, and well-designed, standardised studies evaluating exercise or nutrition interventions are needed before treatment guidelines can be developed.
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Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis.
TL;DR: In this article, the authors performed a systematic review to assess the short-, middle and long-term consequences of sarcopenia, and the results showed a higher rate of mortality among sarcopenic subjects (pooled OR of 3.596 (95% CI 2.96-4.37).
Journal ArticleDOI
Inflammation and sarcopenia: A systematic review and meta-analysis.
Giulia Bano,Caterina Trevisan,S. Carraro,Marco Solmi,Claudio Luchini,Brendon Stubbs,Enzo Manzato,Giuseppe Sergi,Nicola Veronese +8 more
TL;DR: In conclusion, sarcopenia seems to be associated with elevated serum CRP levels; future longitudinal studies are needed to clarify this relationship.
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Roger A. Fielding,Bruno Vellas,William J. Evans,Shalender Bhasin,John E. Morley,Anne B. Newman,Gabor Abellan van Kan,Sandrine Andrieu,Juergen M. Bauer,Denis Breuille,Tommy Cederholm,Julie Chandler,Capucine De Meynard,Lorenzo M. Donini,Tamara B. Harris,Aimo Kannt,Florence Keime Guibert,Graziano Onder,Dimitris Papanicolaou,Yves Rolland,Daniel Rooks,Cornel C. Sieber,Elisabeth Souhami,Sjors Verlaan,Mauro Zamboni +24 more
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Helen C. Roberts,Hayley J Denison,Helen J Martin,Harnish P. Patel,Holly E. Syddall,Cyrus Cooper,Avan Aihie Sayer +6 more
TL;DR: A standardised method of measuring grip strength would enable more consistent measurement of grip strength and better assessment of sarcopenia.
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