SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
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...quartile range) interval from symptom onset to hospital admission is 7 (3-9) days....
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...The mean (interquartile range) incubation period (the time from exposure to symptom onset) for COVID-19 is approximately 5 (2-7) days....
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"SARS-CoV-2 Cell Entry Depends on AC..." refers background in this paper
...Notably, the cleavage site sequence can determine the zoonotic potential of coronaviruses (Menachery et al., 2020; Yang et al., 2014 Yang et al., , 2015 , and a multibasic cleavage site was not present in RaTG13, the coronavirus most closely related to SARS-CoV-2....
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"SARS-CoV-2 Cell Entry Depends on AC..." refers background in this paper
...However, only TMPRSS2 activity is essential for viral spread and pathogenesis in the infected host whereas CatB/L activity is dispensable (Iwata-Yoshikawa et al., 2019; Shirato et al., 2016; Shirato et al., 2018; Zhou et al., 2015)....
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"SARS-CoV-2 Cell Entry Depends on AC..." refers background or result in this paper
...In contrast, most of these residues were absent from S proteins of SARSrCoV previously found not to use ACE2 for entry (Figure 2B) (Ge et al., 2013; Hoffmann et al., 2013; Menachery et al., 2020)....
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...dipeptidyl-peptidase 4 (DPP4) and human TMPRSS2 have been described elsewhere (Bertram et al., 2010; Brinkmann et al., 2017; Gierer et al., 2013; Hoffmann et al., 2013; Hofmann et al., 2005; Kleine-Weber et al., 2019)....
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