SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
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Cites background from "SARS-CoV-2 Cell Entry Depends on AC..."
...quartile range) interval from symptom onset to hospital admission is 7 (3-9) days....
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...The mean (interquartile range) incubation period (the time from exposure to symptom onset) for COVID-19 is approximately 5 (2-7) days....
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References
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"SARS-CoV-2 Cell Entry Depends on AC..." refers background in this paper
...One can speculate that furin-mediated precleavage at the S1/S2 site in infected cells might promote subsequent TMPRSS2-dependent entry into target cells, as reported for MERS-CoV (Kleine-Weber et al., 2018; Park et al., 2016) ....
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266 citations
"SARS-CoV-2 Cell Entry Depends on AC..." refers background in this paper
...This could comprise binding to cellular glycans, a function ascribed to the S1 domain of certain coronaviruses (Li et al., 2017; Park et al., 2019)....
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257 citations
Additional excerpts
..., 2013) N/A Plasmid: pCG1-hAPN (Hofmann et al., 2004a) N/A...
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"SARS-CoV-2 Cell Entry Depends on AC..." refers background in this paper
...Convalescent SARS patients exhibit a neutralizing antibody response that can be detected even 24 months after infection (Liu et al., 2006) and that is largely directed against the S protein....
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...Evidence that Antibodies Raised against SARS-CoV Will Cross-Neutralize SARS-CoV-2 Convalescent SARS patients exhibit a neutralizing antibody response directed against the viral S protein (Liu et al., 2006)....
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236 citations
"SARS-CoV-2 Cell Entry Depends on AC..." refers background in this paper
...In contrast, the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) are transmitted from animals to humans and cause severe respiratory diseases in afflicted individuals, SARS and MERS, respectively (Fehr et al., 2017)....
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