SARS-CoV-2 encoded microRNAs are involved in the process of virus infection and host immune response.
01 Jan 2021-Journal of Biomedical Research (The Journal of Biomedical Research)-Vol. 35, Iss: 3, pp 216-227
TL;DR: In this article, a comprehensive view of the miRNA-involved regulatory system during SARS-CoV-2 infection was provided, indicating possible antiviral therapeutics against SARS CoV2 through intervening miRNA regulation, indicating that the immune response and cytoskeleton organization are two of the most notable biological processes regulated by the infection modulated miRNAs.
About: This article is published in Journal of Biomedical Research.The article was published on 2021-01-01 and is currently open access. It has received 16 citations till now. The article focuses on the topics: Cytoskeleton organization.
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TL;DR: In this paper, the authors present the recent discoveries regarding the clinical relevance and biological roles of miRNAs in coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2.
36 citations
TL;DR: In this article , the authors present the recent discoveries regarding the clinical relevance and biological roles of miRNAs in coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2.
36 citations
TL;DR: A literature search of nine databases was carried out for studies published before 13 June 2021 that described dysregulated miRNAs in cells or animals infected by SARS-CoV-2 or in patients with COVID-19 as discussed by the authors.
Abstract: Aim: miRNAs are potential biomarkers of several diseases. This review aimed to identify the miRNAs that could serve as biomarkers of COVID-19. Materials & methods: A literature search of nine databases was carried out for studies published before 13 June 2021 that described dysregulated miRNAs in cells or animals infected by SARS-CoV-2 or in patients with COVID-19. Two independent reviewers selected the studies and extracted data; disagreements were resolved by a third reviewer. Results: Twenty studies were included in this scoping review; results suggested that miR-21-5p, miR-146a, miR-126-3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. miRNAs appear to play key roles in viral replication, proliferation of infected cells, immune response, inflammation and cardiovascular dysfunction. Conclusion: This review provides insights into the role of miRNAs as biomarkers in COVID-19 and the current status and future directions for research in this field.
13 citations
TL;DR: In this article , the authors summarized the data about dysregulation of miRNAs in COVID-19 and evaluated the immune-related aspect of this disorder to identify the host-related factors that affect the course of COVID19.
7 citations
TL;DR: Through computational prediction of the SARS-CoV-2 viral genome sequence and vmiRNA screening analysis of the samples from covid-19 patients, the only vmiRNAs primarily predicted from the SATS viral genome are successfully identified and further validated in the Sars-Co V-2-infected Vero E6 cells.
5 citations
References
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TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
36,578 citations
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
15,362 citations
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
Abstract: Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health1–3. Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. As of 25 January 2020, at least 1,975 cases had been reported since the first patient was hospitalized on 12 December 2019. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan. Here we study a single patient who was a worker at the market and who was admitted to the Central Hospital of Wuhan on 26 December 2019 while experiencing a severe respiratory syndrome that included fever, dizziness and a cough. Metagenomic RNA sequencing4 of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here ‘WH-Human 1’ coronavirus (and has also been referred to as ‘2019-nCoV’). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that the virus was most closely related (89.1% nucleotide similarity) to a group of SARS-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) that had previously been found in bats in China5. This outbreak highlights the ongoing ability of viral spill-over from animals to cause severe disease in humans. Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
9,231 citations
5,446 citations