Satellite Cells and the Muscle Stem Cell Niche
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TLDR
For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved the understanding of skeletal muscle biology, with focuses on functions of satellite cells and their niche during the process ofletal muscle regeneration.Abstract:
Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated process invol...read more
Citations
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Journal ArticleDOI
Autophagy maintains stemness by preventing senescence
Laura García-Prat,Marta Martinez-Vicente,Eusebio Perdiguero,Laura Ortet,Javier Rodríguez-Ubreva,Elena Rebollo,Ruiz-Bonilla,Susana Gutarra,Esteban Ballestar,Antonio L. Serrano,Marco Sandri,Pura Muñoz-Cánoves +11 more
TL;DR: It is reported that basal autophagy is essential to maintain the stem-cell quiescent state in mice and revealed to be a decisive stem- cell-fate regulator, with implications for fostering muscle regeneration in sarcopenia.
Journal ArticleDOI
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Hongbo Zhang,Dongryeol Ryu,Yibo Wu,Karim Gariani,Xu Wang,Peiling Luan,Davide D'Amico,Eduardo R. Ropelle,Eduardo R. Ropelle,Matthias P. Lutolf,Ruedi Aebersold,Ruedi Aebersold,Kristina Schoonjans,Keir J. Menzies,Keir J. Menzies,Johan Auwerx +15 more
TL;DR: It is demonstrated the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD+) and its effect on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence and it is demonstrated that NR delays senescences of neural SCs and melanocyteSCs and increases mouse life span.
Journal ArticleDOI
Geriatric muscle stem cells switch reversible quiescence into senescence
Pedro Sousa-Victor,Pedro Sousa-Victor,Susana Gutarra,Laura García-Prat,Javier Rodríguez-Ubreva,Laura Ortet,Vanessa Ruiz-Bonilla,Mercè Jardí,Esteban Ballestar,Susana González,Antonio L. Serrano,Eusebio Perdiguero,Pura Muñoz-Cánoves,Pura Muñoz-Cánoves +13 more
TL;DR: It is reported that geriatric satellite cells are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and that this irreversibly affects their intrinsic regenerative and self-renewal capacities.
Journal ArticleDOI
Sarcopenia: Aging-Related Loss of Muscle Mass and Function.
Lars Larsson,Hans Degens,Meishan Li,Leonardo Salviati,Youngil Lee,Wesley J. Thompson,James L. Kirkland,Marco Sandri +7 more
TL;DR: This review focuses on the aging-related structural changes and mechanisms at cellular and subcellular levels underlying changes in the individual motor unit: specifically, the perikaryon of the α-motoneuron, its neuromuscular junction(s), and the muscle fibers that it innervates.
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Prevention of muscular dystrophy in mice by CRISPR/Cas9–mediated editing of germline DNA
Chengzu Long,John R. McAnally,John M. Shelton,Alex A. Mireault,Rhonda Bassel-Duby,Eric N. Olson +5 more
TL;DR: A mutation that causes muscular dystrophy in mice can be corrected by genome editing, which prevents the disease from developing, and this proof of concept sets the stage for applying genome editing to specific cell types involved in the disease.
References
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