Journal ArticleDOI
Self-assembly in nature: using the principles of nature to create complex nanobiomaterials.
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TLDR
The motivation of this review is to provide an overview on the design principles for peptide self- assembly and to illustrate how these principles have been applied to manipulate their self-assembly across the scales.Abstract:
Self-assembly is a ubiquitous process in biology where it plays numerous important roles and underlies the formation of a wide variety of complex biological structures. Over the past two decades, materials scientists have aspired to exploit nature's assembly principles to create artificial materials, with hierarchical structures and tailored properties, for the fabrication of functional devices. Toward this goal, both biological and synthetic building blocks have been subject of extensive research in self-assembly. In fact, molecular self-assembly is becoming increasingly important for the fabrication of biomaterials because it offers a great platform for constructing materials with high level of precision and complexity, integrating order and dynamics, to achieve functions such as stimuli-responsiveness, adaptation, recognition, transport, and catalysis. The importance of peptide self-assembling building blocks has been recognized in the last years, as demonstrated by the literature available on the topic. The simple structure of peptides, as well as their facile synthesis, makes peptides an excellent family of structural units for the bottom-up fabrication of complex nanobiomaterials. Additionally, peptides offer a great diversity of biochemical (specificity, intrinsic bioactivity, biodegradability) and physical (small size, conformation) properties to form self-assembled structures with different molecular configurations. The motivation of this review is to provide an overview on the design principles for peptide self-assembly and to illustrate how these principles have been applied to manipulate their self-assembly across the scales. Applications of self-assembling peptides as nanobiomaterials, including carriers for drug delivery, hydrogels for cell culture and tissue repair are also described.read more
Citations
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Molecular self-assembly and nanochemistry: A chemical strategy for the synthesis of nanostructures
TL;DR: In this article, self-assembly is defined as the spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates joined by noncovalent bonds.
Journal ArticleDOI
Fmoc-modified amino acids and short peptides: simple bio-inspired building blocks for the fabrication of functional materials
TL;DR: Amino acids and short peptides modified with the 9-fluorenylmethyloxycarbonyl (Fmoc) group possess eminent self-assembly features and show distinct potential for applications due to the inherent hydrophobicity and aromaticity of the Fmoc moiety which can promote the association of building blocks.
Journal ArticleDOI
Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications.
Armin Vedadghavami,Farnaz Minooei,Mohammad Hossein Mohammadi,Sultan Khetani,Ahmad Rezaei Kolahchi,Shohreh Mashayekhan,Amir Sanati-Nezhad +6 more
TL;DR: The most common approaches used for tuning mechanical properties of hydrogels including but are not limited to, interpenetrating polymer networks, nanocomposites, self-assembly techniques, and co-polymerization are discussed.
Journal ArticleDOI
Hierarchically oriented organization in supramolecular peptide crystals
TL;DR: Yuan et al. as mentioned in this paper proposed the concept of hierarchically oriented organization for self-assembling peptide crystals, distinct from the traditional growth mechanism of supramolecular polymerization and crystallization based on the Ostwald ripening rule.
Journal ArticleDOI
Control of polymeric nanoparticle size to improve therapeutic delivery
TL;DR: Three notable techniques best suited for generating polymeric NPs with narrow size distributions are highlighted in this review and the effect of NP size on the biological fate and transport properties at the molecular scale and the tissue and systemic scale are analyzed.
References
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Journal ArticleDOI
Self-assembly at all scales.
TL;DR: Self-assembling processes are common throughout nature and technology and involve components from the molecular to the planetary scale and many different kinds of interactions.
Journal ArticleDOI
Biological roles of oligosaccharides: all of the theories are correct
TL;DR: The only common features of the varied functions of oligosaccharides are that they either mediate ‘specific recognition’ events or that they provide ‘modulation’ of biological processes.
PatentDOI
Self-assembly and mineralization of peptide-amphiphile nanofibers
TL;DR: In this paper, pH-induced self-assembly of a peptide-amphiphile was used to make a nanostructured fibrous scaffold reminiscent of extracellular matrix.
Journal ArticleDOI
Molecular self-assembly and nanochemistry: a chemical strategy for the synthesis of nanostructures.
TL;DR: The ability to prepare structures in the upper part of this range of sizes would open a route to structures comparable in size (and perhaps complementary in function) to those that can be prepared by microlithography and other techniques of microfabrication.
Journal ArticleDOI
Empirical predictions of protein conformation.
Peter Y. Chou,Gerald D. Fasman +1 more