Journal ArticleDOI
Self-Healing Silk Fibroin-Based Hydrogel for Bone Regeneration: Dynamic Metal-Ligand Self-Assembly Approach
Liyang Shi,Fanlu Wang,Wei Zhu,Zongpu Xu,Sabine Fuchs,Jöns Hilborn,Liangjun Zhu,Qi Ma,Yingjie Wang,Xisheng Weng,Dmitri A. Ossipov +10 more
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TLDR
A strategy based on dynamic metal‐ligand coordination chemistry is developed to assemble SF‐based hydrogel under physiological conditions between SF microfibers and a polysaccharide binder, which possesses significant potential for bone regeneration application with the advantages of injectability and fit‐to‐shape molding.Abstract:
Despite advances in the development of silk fibroin (SF)-based hydrogels, current methods for SF gelation show significant limitations such as lack of reversible crosslinking, use of nonphysiological conditions, and difficulties in controlling gelation time. In the present study, a strategy based on dynamic metal-ligand coordination chemistry is developed to assemble SF-based hydrogel under physiological conditions between SF microfibers (mSF) and a polysaccharide binder. The presented SF-based hydrogel exhibits shear-thinning and autonomous self-healing properties, thereby enabling the filling of irregularly shaped tissue defects without gel fragmentation. A biomineralization approach is used to generate calcium phosphate-coated mSF, which is chelated by bisphosphonate ligands of the binder to form reversible crosslinkages. Robust dually crosslinked (DC) hydrogel is obtained through photopolymerization of acrylamide groups of the binder. DC SF-based hydrogel supports stem cell proliferation in vitro and accelerates bone regeneration in cranial critical size defects without any additional morphogenes delivered. The developed self-healing and photopolymerizable SF-based hydrogel possesses significant potential for bone regeneration application with the advantages of injectability and fit-to-shape molding.read more
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Journal ArticleDOI
Materials design for bone-tissue engineering
TL;DR: In this paper, the authors provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modelling and treatment of injuries and disease in humans, and highlight scalable technologies that can fabricate natural and synthetic biomaterials (polymers, bioceramics, metals and composites) into forms suitable for bone tissue engineering applications in human therapies and disease models.
Journal ArticleDOI
3D printing of hydrogels: Rational design strategies and emerging biomedical applications
TL;DR: A review of hydrogel-based biomaterial inks and bioinks for 3D printing can be found in this paper, where the authors provide a comprehensive overview and discussion of the tailorability of material, mechanical, physical, chemical and biological properties.
Journal ArticleDOI
Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?
Sepehr Talebian,Mehdi Mehrali,Nayere Taebnia,Cristian Pablo Pennisi,Firoz Babu Kadumudi,Javad Foroughi,Masoud Hasany,Mehdi Nikkhah,Mohsen Akbari,Gorka Orive,Alireza Dolatshahi-Pirouz,Alireza Dolatshahi-Pirouz +11 more
TL;DR: The recent progress in the development of multifunctional and self‐healable hydrogels for various tissue engineering applications is discussed in detail and their potential applications within the rapidly expanding areas of bioelectronics, cyborganics, and soft robotics are highlighted.
Journal ArticleDOI
Self-healing conductive hydrogels: preparation, properties and applications
TL;DR: The self-healing mechanism is classified to demonstrate the design and synthesis of conductive self- healing hydrogels and their applications in tissue engineering, wound healing, electronic skin, sensors and self-repaired circuits are presented.
Journal ArticleDOI
Self-Healable Multifunctional Electronic Tattoos Based on Silk and Graphene
TL;DR: In this article, a healing and multifunctional E-tattoo based on a graphene/silk fibroin/Ca2+ (Gr/SF/Ca 2+) combination is reported, which is capable of self-healing and sensing multistimuli.
References
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Journal ArticleDOI
Materials fabrication from Bombyx mori silk fibroin
Danielle N. Rockwood,Rucsanda C. Preda,Tuna Yucel,Xiaoqin Wang,Michael L. Lovett,David L. Kaplan +5 more
TL;DR: This protocol includes methods to extract silk from B. mori cocoons to fabricate hydrogels, tubes, sponges, composites, fibers, microspheres and thin films, used directly as biomaterials for implants, as scaffolding in tissue engineering and in vitro disease models, as well as for drug delivery.
Journal ArticleDOI
Biomaterial developments for bone tissue engineering
TL;DR: The clinical need for bone tissue-engineered alternatives to the present materials used in bone grafting techniques is presented, a status report on clinically availableBone tissue-engineering devices, and recent advances in biomaterials research are presented.