Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.

doi:10.1016/J.JCONREL.2003.12.021

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Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.

Journal Article•DOI•

Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.

Fariyal Ahmed¹, Dennis E. Discher¹•Institutions (1)

University of Pennsylvania¹

16 Apr 2004-Journal of Controlled Release (Elsevier)-Vol. 96, Iss: 1, pp 37-53

TL;DR: With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.

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About: This article is published in Journal of Controlled Release.The article was published on 2004-04-16. It has received 638 citations till now. The article focuses on the topics: Controlled release & Polymersome.

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Journal Article•DOI•

Polymer-based nanocapsules for drug delivery

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Claudia Elizabeth Mora-Huertas¹, Hatem Fessi¹, Abdelhamid Elaissari¹•Institutions (1)

University of Lyon¹

29 Jan 2010-International Journal of Pharmaceutics

TL;DR: A comparative analysis is given of the size, zeta-potential, dispersion pH, shell thickness, encapsulation efficiency, active substance release, stability and in vivo and in vitro pharmacological performances, which allows establishing criteria for selecting a method for preparation of nanocapsules according to its advantages, limitations and behaviours as a drug carrier.

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1,462 citations

Cites background from "Self-porating polymersomes of PEG-P..."

...Some examples of active substances encapsulated are mainly anti- al., 2006) and doxorubicin (Ahmed and Discher, 2004; Zheng et al., 2009), therapeutic proteins and antisense molecules for gene therapy (Christian et al., 2009; Kim et al., 2009)....
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Journal Article•DOI•

Self-Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications.

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Adam Blanazs¹, Steven P. Armes¹, Anthony J. Ryan¹•Institutions (1)

University of Sheffield¹

18 Feb 2009-Macromolecular Rapid Communications

TL;DR: This review is focused on the inherent advantages in using polymer vesicles over their small molecule lipid counterparts and the potential applications in biology for both drug delivery and synthetic cellular reactors.

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Abstract: The ability of amphiphilic block copolymers to self-assemble in selective solvents has been widely studied in academia and utilized for various commercial products. The self-assembled polymer vesicle is at the forefront of this nanotechnological revolution with seemingly endless possible uses, ranging from biomedical to nanometer-scale enzymatic reactors. This review is focused on the inherent advantages in using polymer vesicles over their small molecule lipid counterparts and the potential applications in biology for both drug delivery and synthetic cellular reactors.

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1,320 citations

Journal Article•DOI•

Stimuli-responsive polymersomes for programmed drug delivery.

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Fenghua Meng¹, Zhiyuan Zhong¹, Jan Feijen¹•Institutions (1)

Soochow University (Suzhou)¹

05 Jan 2009-Biomacromolecules

TL;DR: In this article, recent advances in stimuli-sensitive polymersomes have been reviewed, and perspectives on future developments have been discussed.

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1,020 citations

Journal Article•DOI•

A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes.

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Kevin Letchford¹, Helen M. Burt¹•Institutions (1)

University of British Columbia¹

01 Mar 2007-European Journal of Pharmaceutics and Biopharmaceutics

TL;DR: This review attempts to clarify some of the terminology used in the literature by providing an overview of the major features of each type of nanoparticle and the factors that influence the formation of particular nanoparticulate formulations.

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1,020 citations

Journal Article•DOI•

Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications ☆

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Emanuel Fleige¹, Mohiuddin A. Quadir², Rainer Haag¹•Institutions (2)

Free University of Berlin¹, University of Dhaka²

15 Jun 2012-Advanced Drug Delivery Reviews

TL;DR: This review gives a brief overview about some types of stimuli-responsive nanocarriers with the main focus on organic polymer-based systems.

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963 citations

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References

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Journal Article•DOI•

Biodegradable long-circulating polymeric nanospheres

[...]

Ruxandra Gref¹, Yoshiharu Minamitake¹, Maria Teresa Peracchia¹, Vladimir S. Trubetskoy¹, Vladimir P. Torchilin¹, Robert Langer¹ - Show less +2 more•Institutions (1)

Massachusetts Institute of Technology¹

18 Mar 1994-Science

TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.

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Abstract: Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these limitations, monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks. The nanospheres exhibited dramatically increased blood circulation times and reduced liver accumulation in mice. Furthermore, they entrapped up to 45 percent by weight of the drug in the dense core in a one-step procedure and could be freeze-dried and easily redispersed without additives in aqueous solutions.

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2,827 citations

"Self-porating polymersomes of PEG-P..." refers background in this paper

...Whereas diblock copolymers with small hydrophilic PEG fractions of fEO<20% and large MW hydrophobic blocks exhibit a strong propensity for sequestering their immobile hydrophobic blocks into solid-like particles (for PEG–PLA [21,26,37]), an increased fEO f20– 42% generally shifts the assembly towards more fluidlike vesicles [27,28,30,38–43] or other ‘‘loose’’ micellar architectures [44–46]....
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...Particulate systems, on the other hand, display distinct biphasic burst profiles with repartitioning and leakage of a lipophilic drug varying from minutes to tens of hours [21,26]....
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...Considerable work has already been done on the mechanism of this water-initiated reaction [75], and it is well understood that the degradation of large molecular weight PLA blocks, self-assembled as either micelle or nanoparticles, takes on the order of months [21]....
[...]

Journal Article•DOI•

Block Copolymers—Designer Soft Materials

[...]

Frank S. Bates, Glenn H. Fredrickson¹•Institutions (1)

University of California, Santa Barbara¹

01 Feb 1999-Physics Today

TL;DR: The Knitting Pattern as mentioned in this paper is a block copolymer that was discovered by Reimund Stadler and his coworkers and reflects a delicate free-energy minimization that is common to all blockcopolymer materials.

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Abstract: Block copolymers are all around us, found in such products as upholstery foam, adhesive tape and asphalt additives. This class of macromolecules is produced by joining two or more chemically distinct polymer blocks, each a linear series of identical monomers, that may be thermodynamically incompatible (like oil and vinegar). Segregation of these blocks on the molecular scale (5–100 nm) can produce astonishingly complex nanostructures, such as the “knitting pattern” shown on the cover of this issue of PHYSICS TODAY. This striking pattern, discovered by Reimund Stadler and his coworkers, reflects a delicate free‐energy minimization that is common to all block copolymer materials.

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2,824 citations

"Self-porating polymersomes of PEG-P..." refers background in this paper

...Extensive theoretical [34,35] as well as general experimental studies of block copolymer amphiphiles have established that aggregate morphology, in dilution, is principally determined by molecular geometry....
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Journal Article•

Polymer vesicles : Materials science: Soft surfaces

[...]

Dennis E. Discher, Adi Eisenberg

01 Jan 2002-Science

TL;DR: Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date underscore the fact that biologically derived vesicle are but a small subset of what is physically and chemically possible.

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Abstract: Vesicles are microscopic sacs that enclose a volume with a molecularly thin membrane. The membranes are generally self-directed assemblies of amphiphilic molecules with a dual hydrophilic-hydrophobic character. Biological amphiphiles form vesicles central to cell function and are principally lipids of molecular weight less than 1 kilodalton. Block copolymers that mimic lipid amphiphilicity can also self-assemble into vesicles in dilute solution, but polymer molecular weights can be orders of magnitude greater than those of lipids. Structural features of vesicles, as well as properties including stability, fluidity, and intermembrane dynamics, are greatly influenced by characteristics of the polymers. Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date already underscore the fact that biologically derived vesicles are but a small subset of what is physically and chemically possible.

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2,423 citations

Journal Article•DOI•

Biodegradation and biocompatibility of PLA and PLGA microspheres

[...]

James M. Anderson¹, Matthew S. Shive¹•Institutions (1)

Case Western Reserve University¹

13 Oct 1997-Advanced Drug Delivery Reviews

TL;DR: This chapter is a critical review of biodegradation, biocompatibility and tissue/material interactions, and selected examples of PLA and PLGA microsphere controlled release systems, and emphasis is placed on polymer and microSphere characteristics which modulate the degradation behaviour and the foreign body reaction to the microspheres.

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2,351 citations

Journal Article•DOI•

Polymersomes: tough vesicles made from diblock copolymers.

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Bohdana M. Discher¹, You-Yeon Won², David S. Ege¹, James C. Lee¹, Frank S. Bates², Dennis E. Discher¹, Daniel A. Hammer¹ - Show less +3 more•Institutions (2)

University of Pennsylvania¹, University of Minnesota²

14 May 1999-Science

TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.

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Abstract: Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation. The average molecular weight of the specific polymer studied, polyethyleneoxide-polyethylethylene (EO40-EE37), is several times greater than that of typical phospholipids in natural membranes. Both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements, but the giant polymersomes proved to be almost an order of magnitude tougher and sustained far greater areal strain before rupture. The polymersome membrane was also at least 10 times less permeable to water than common phospholipid bilayers. The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry.

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2,338 citations

"Self-porating polymersomes of PEG-P..." refers background or methods in this paper

...Polymer vesicles change shape by swelling and shrinking osmotically [ 30 ], which indicates that water permeates the core of the membrane....
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...In addition, osmotically driven shape and volume changes of such giant vesicles [ 30 ] allow visual proof that water necessarily permeates the membrane, which is a pre-requisite for hydrolytic cleavage....
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...Selfassembled vesicle of PEG–PLA diblock copolymer OL1, and several worm-like and spherical aggregates of the inert block copolymer of hydrogenated PEG–PBD [ 30 ]....
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...Vesicle formulations of PEG–PLA or PEG–PCL with or without inert PEG–PBD (polybutadiene)—a welldocumented vesicle former in water [ 30 ]—are shown here to provide programmed control over release kinetics....
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