Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
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...Confirming and extending pre- vious observations (Ozerdem et al., 2002; Middleton et al., 2005; Sacchetti et al., 2007), we have validated the CD146+ NG2+ PDGFRb+ ALP+ CD34 CD45 vWF CD144 phenotype as an indicator of pericyte/perivascular cell identity throughout hu- man fetal and adult organs....
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...Interestingly, a population of CD146+ subendothelial cells in human bone mar- row contains osteogenic progenitors that are also at the origin of the stromal cells that support hematopoiesis (Sacchetti et al., 2007)....
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...…associated with pericytes during vascular morphogenesis (Ozerdem et al., 2002) and CD146 (aka S-endo1, Mel-CAM, Muc18, or gicerin), an endothelial cell antigen also expressed at the surface of peri- cytes (Li et al., 2003; Middleton et al., 2005; Sacchetti et al., 2007) (Figures 1A–1C and 1G)....
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...for Mesenchymal Stem Cells in Multiple Human Organs...
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3,142 citations
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...However, in the bone marrow, stromal cells are a rare and heterogeneous population of cells that contain a mixture of progenitors at different stages of commitment to the mesodermal lineage and only a very small number of multipotential self-renewing stem cells, which have recently been identified as sub-endothelial cells that express CD146 (also known as MCAM...
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3,012 citations
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...Angiopoietin-1 expression has been attributed to both osteoblasts at the endosteum (Arai et al., 2004) and to perivascular mesenchymal progenitors (Sacchetti et al., 2007)....
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...Perivascular reticular cells and mesenchymal progenitors have also been proposed to elaborate factors that regulate HSC maintenance (Sacchetti et al., 2007; Sugiyama et al., 2006)....
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..., 2004) and to perivascular mesenchymal progenitors (Sacchetti et al., 2007)....
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...The chemokine CXCL12 (SDF-1) is required for the maintenance of bone marrow HSCs and is expressed by both perivascular and endosteal cells (Kollet et al., 2006; Sacchetti et al., 2007; Sugiyama et al., 2006)....
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References
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"Self-Renewing Osteoprogenitors in B..." refers background in this paper
...The multipotency of at least a subset of CFU-Fs supports the view that a second type of stem cell (skeletal [Bianco and Robey, 2004], stromal [Owen and Friedenstein, 1988], or ‘‘mesenchymal’’ [Caplan, 1991]) coexists with HSCs in BM....
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...…CFU-Fs supports the view that a second type of stem cell (skeletal [Bianco and Robey, 2004], stromal [Owen and Friedenstein, 1988], or ‘‘mesenchymal’’ [Caplan, 1991]) coexists with HSCs in BM. Due to the lack of markers suited to bridge the gap between in situ, ex vivo, and in vivo observations,…...
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3,434 citations
"Self-Renewing Osteoprogenitors in B..." refers background in this paper
...The multipotency of at least a subset of CFU-Fs supports the view that a second type of stem cell (skeletal [Bianco and Robey, 2004], stromal [Owen and Friedenstein, 1988], or ‘‘mesenchymal’’ [Caplan, 1991]) coexists with HSCs in BM. Due to the lack of markers suited to bridge the gap between in situ, ex vivo, and in vivo observations, the in situ counterpart of CFU-Fs has previously remained unknown, and the Cell 131, 324–336, October 19, 2007 ª2007 Elsevier Inc. 331 (A) Ang-1 immunoreactivity in sections of human BM is restricted to ARCs (arrows) and absent over bone surfaces. ad, adipocytes....
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...For example, CD146+ subendothelial cells ex- 334 Cell 131, 324–336, October 19, 2007 ª2007 Elsevier Inc. pressing HSC regulators such as Ang-1 or CXCL12 would be strategically positioned to facilitate the homing of blood borne hematopoietic progenitors to the marrow environment or to contribute to a steady-state sinusoidal niche where HSCs can be localized....
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...As (self-renewing) progenitors of sinusoidal adventitial reticular cells, CD146+ stromal cells contribute to the organization, and become an integral part, of the structure of sinusoidal walls, in the vicinities of which HSCs have been directly localized (Kiel et al., 2005)....
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...A body of evidence also suggests that endosteal (Calvi et al., 2003; Zhang et al., 2003) and sinusoidal surfaces (Kiel et al., 2005), but also CXCL12-expressing ‘‘reticular’’ cells within the hematopoietic space (Sugiyama et al., 2006), may represent specific sites of HSC regulation (‘‘niches’’)....
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...Cell 131, 324–336, October 19, 2007 ª2007 Elsevier Inc. 333 ligand of the Tie-2 receptor that is specifically expressed in ECs and HSCs, Ang-1 plays pivotal roles both in angiogenesis and hematopoiesis....
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3,091 citations
"Self-Renewing Osteoprogenitors in B..." refers background in this paper
..., 2003), as well as to endothelial cells lining sinusoids (Kiel et al., 2005), suggesting a potential multiplicity of physiologically important...
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...and sinusoidal surfaces (Kiel et al., 2005), but also CXCL12-expressing ‘‘reticular’’ cells within the hematopoietic space (Sugiyama et al....
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...As (self-renewing) progenitors of sinusoidal adventitial reticular cells, CD146+ stromal cells contribute to the organization, and become an integral part, of the structure of sinusoidal walls, in the vicinities of which HSCs have been directly localized (Kiel et al., 2005)....
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...A body of evidence also suggests that endosteal (Calvi et al., 2003; Zhang et al., 2003) and sinusoidal surfaces (Kiel et al., 2005), but also CXCL12-expressing ‘‘reticular’’ cells within the hematopoietic space (Sugiyama et al., 2006), may represent specific sites of HSC regulation (‘‘niches’’)....
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...of sinusoidal walls, in the vicinities of which HSCs have been directly localized (Kiel et al., 2005)....
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