Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life.
01 May 2013-The American Journal of Gastroenterology (Nature Publishing Group)-Vol. 108, Iss: 5, pp 634-641
TL;DR: The majority of IBS patients believe that certain food items are important triggers of their GI symptoms, and this is especially true for foods containing carbohydrates and fat, and also may be relevant for histamine-releasing food items and foods rich in biogenic amines.
About: This article is published in The American Journal of Gastroenterology.The article was published on 2013-05-01. It has received 478 citations till now. The article focuses on the topics: Irritable bowel syndrome.
Citations
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TL;DR: In a controlled, cross-over study of patients with IBS, a diet low in FODMAPs effectively reduced functional gastrointestinal symptoms and high-quality evidence supports its use as a first-line therapy.
996 citations
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Paul Enck1, Qasim Aziz2, Giovanni Barbara3, Adam D. Farmer2, Shin Fukudo4, Emeran A. Mayer5, Beate Niesler6, Eamonn Martin Quigley7, Mirjana Rajilić-Stojanović8, Michael Schemann9, Juliane Schwille-Kiuntke1, Magnus Simren10, Stephan Zipfel1, Robin C. Spiller11 •
University of Tübingen1, Queen Mary University of London2, University of Bologna3, Tohoku University4, University of California, Los Angeles5, Heidelberg University6, Cornell University7, University of Belgrade8, Technische Universität München9, University of Gothenburg10, University of Nottingham11
TL;DR: The past decade has seen remarkable progress in the understanding of functional bowel disorders such as IBS that will be summarized in this Primer.
Abstract: A 28-year-old woman presents with a 7-month history of recurrent, crampy pain in the left lower abdominal quadrant, bloating with abdominal distention, and frequent, loose stools. She reports having had similar but milder symptoms since childhood. She spends long times in the bathroom because she is worried about uncontrollable discomfort and fecal soiling if she does not completely empty her bowels before leaving the house. She feels anxious and fatigued and is frustrated that her previous physician did not seem to take her distress seriously. Physical examination is unremarkable except for tenderness over the left lower quadrant. How should her case be evaluated and treated?
635 citations
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TL;DR: A diet low in FODMAPs reduces IBS symptoms as well as traditional IBS dietary advice, and combining elements from these 2 strategies might further reduce symptoms of IBS.
478 citations
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TL;DR: This review describes pathways (mechanisms) by which diet components, via the microbial fermentation, could trigger IBS symptoms and suggests recommendations for future studies that would enable elucidation of the role of diet and microbiota and how these factors may be (inter)related in the pathophysiology of IBS.
288 citations
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TL;DR: This first-ever American College of Gastroenterology clinical guideline for the management of IBS recommends that a positive diagnostic strategy as compared to a diagnostic strategy of exclusion be used to improve time to initiating appropriate therapy and recommends gut-directed psychotherapy to treat global IBS symptoms.
282 citations
References
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TL;DR: It is suggested that the introduction of the scales into general hospital practice would facilitate the large task of detection and management of emotional disorder in patients under investigation and treatment in medical and surgical departments.
Abstract: A self-assessment scale has been developed and found to be a reliable instrument for detecting states of depression and anxiety in the setting of an hospital medical outpatient clinic. The anxiety and depressive subscales are also valid measures of severity of the emotional disorder. It is suggested that the introduction of the scales into general hospital practice would facilitate the large task of detection and management of emotional disorder in patients under investigation and treatment in medical and surgical departments.
35,518 citations
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TL;DR: Employing a consensus approach, the working team critically considered the available evidence and multinational expert criticism, revised the Rome II diagnostic criteria for the functional bowel disorders, and updated diagnosis and treatment recommendations.
4,302 citations
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TL;DR: The PHQ-15 is a brief, self-administered questionnaire that may be useful in screening for somatization and in monitoring somatic symptom severity in clinical practice and research.
Abstract: OBJECTIVE Somatization is prevalent in primary care and is associated with substantial functional impairment and healthcare utilization. However, instruments for identifying and monitoring somatic symptoms are few in number and not widely used. Therefore, we examined the validity of a brief measure of the severity of somatic symptoms. METHODS The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-15 comprises 15 somatic symptoms from the PHQ, each symptom scored from 0 ("not bothered at all") to 2 ("bothered a lot"). The PHQ-15 was administered to 6000 patients in eight general internal medicine and family practice clinics and seven obstetrics-gynecology clinics. Outcomes included functional status as assessed by the 20-item Short-Form General Health Survey (SF-20), self-reported sick days and clinic visits, and symptom-related difficulty. RESULTS As PHQ-15 somatic symptom severity increased, there was a substantial stepwise decrement in functional status on all six SF-20 subscales. Also, symptom-related difficulty, sick days, and healthcare utilization increased. PHQ-15 scores of 5, 10, 15, represented cutoff points for low, medium, and high somatic symptom severity, respectively. Somatic and depressive symptom severity had differential effects on outcomes. Results were similar in the primary care and obstetrics-gynecology samples. CONCLUSIONS The PHQ-15 is a brief, self-administered questionnaire that may be useful in screening for somatization and in monitoring somatic symptom severity in clinical practice and research.
2,451 citations
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TL;DR: The prevalence of IBS varies among countries, as well as criteria used to define its presence, and women are at slightly higher risk for IBS than men.
1,620 citations
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TL;DR: A better knowledge of the factors controlling the formation of amines is necessary in order to improve the quality and safety of food as discussed by the authors, which can be found in both raw and processed foods.
1,283 citations