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Journal ArticleDOI

Separation by Flow

01 Mar 1970-Macromolecules-Vol. 3, Iss: 2, pp 131-146
About: This article is published in Macromolecules.The article was published on 1970-03-01. It has received 204 citations till now. The article focuses on the topics: Flow (mathematics).
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Journal ArticleDOI
14 May 2004-Science
TL;DR: A microfluidic particle-separation device that makes use of the asymmetric bifurcation of laminar flow around obstacles, which was better than the time and resolution of conventional flow techniques.
Abstract: We report on a microfluidic particle-separation device that makes use of the asymmetric bifurcation of laminar flow around obstacles. A particle chooses its path deterministically on the basis of its size. All particles of a given size follow equivalent migration paths, leading to high resolution. The microspheres of 0.8, 0.9, and 1.0 micrometers that were used to characterize the device were sorted in 40 seconds with a resolution of approximately 10 nanometers, which was better than the time and resolution of conventional flow techniques. Bacterial artificial chromosomes could be separated in 10 minutes with a resolution of approximately 12%.

1,513 citations

Journal ArticleDOI
03 Sep 2004-Langmuir
TL;DR: The design, fabrication, and operation of microfluidic chemical reactors for the synthesis of colloidal silica particles, and particle sizes and size distributions with varying linear flow velocity and mean residence time are demonstrated.
Abstract: We demonstrate the design, fabrication, and operation of microfluidic chemical reactors for the synthesis of colloidal silica particles. Two reactor configurations are examined: laminar flow reactors and segmented flow reactors. We analyze particle sizes and size distributions and examine their change with varying linear flow velocity and mean residence time. Laminar flow reactors are affected by axial dispersion at high linear velocities, thus leading to wide particle size distributions under these conditions. Gas is used to create a segmented flow, consisting liquid plugs separated by inert gas bubbles. The internal recirculation created in the liquid plugs generates mixing, which eliminates the axial dispersion effects associated with laminar flow reactors and produces a narrow size distribution of silica nanoparticles.

399 citations

Journal ArticleDOI
TL;DR: In this article, the effect of a constraining circular cylindrical boundary on the translational Brownian motion of an isolated spherical particle suspended in a Poiseuille flow is investigated.

386 citations

Journal ArticleDOI
01 Jul 1974
TL;DR: In this paper, a chromatographic technique called hydrodynamic chromatography has been developed, which can yield size information on a variety of colloidal materials in the submicron range.
Abstract: When colloidal materials are carried in aqueous suspension through packed beds of spherical particles, it has been observed that the rate of transport of the colloidal particles depends on such factors as the size of the colloid, the size of the packing and the ionic composition of the aqueous phase. From such observations, a chromatographic technique has been developed, called hydrodynamic chromatography, which can yield size information on a variety of colloidal materials in the submicron range. Several examples are provided that illustrate how the technique is applied in the study of polymer latexes to determine particle size, assess particle size distribution, follow emulsion polymerization kinetics and provide evidence for particle agglomeration. The origin of the various transport and separation phenomena is also discussed.

281 citations