Journal ArticleDOI
Serogroups of Pseudomonas aeruginosa and the immune response of patients with cystic fibrosis.
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TLDR
The antibody response of patients with cystic fibrosis harboring P. aeruginosa was determined and, in addition, all isolates were grouped serologically according to O antigens.Abstract:
It is well known that patients with cystic fibrosis are prone to chronic infections of the respiratory tract [1,2]. Increasingly often Pseudomonas aeruginosa is the responsible microorganism in both its nonmucoid and mucoid forms [2, 3]. Its contribution to the pathogenesis of the lung involvement has not been definitely ascertained [3]. It is assumed that active infection rather than surface colonization must take place in order to elicit a specific immune response. Therefore, in this study the antibody response of patients with cystic fibrosis harboring P. aeruginosa was determined and, in addition, all isolates were grouped serologically according to O antigens.read more
Citations
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Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.
John R. W. Govan,Vojo Deretic +1 more
TL;DR: This review summarizes the latest advances in understanding host-pathogen interactions in CF with an emphasis on the role and control of conversion to mucoidy in P. aeruginosa and B. cepacia.
Journal ArticleDOI
Production and Characterization of the Slime Polysaccharide of Pseudomonas aeruginosa
Leigh R. Evans,Alfred Linker +1 more
TL;DR: The slime polysaccharides produced by Pseudomonas aeruginosa isolated from a variety of human infections were investigated and were found to be similar to each other, to the slime of Azotobacter vinelandii, and to seaweed alginic acids.
Journal ArticleDOI
Alginate synthesis by Pseudomonas aeruginosa: a key pathogenic factor in chronic pulmonary infections of cystic fibrosis patients.
Thomas B. May,Dean Shinabarger,R Maharaj,Junichi Kato,L Chu,J. D. DeVault,Siddhartha Roychoudhury,Nicolette A. Zielinski,Alan Berry,R K Rothmel +9 more
TL;DR: Reports on the role of alginate in cystic fibrosis-associated pulmonary infections caused by P. aeruginosa are summarized and details about the biosynthesis and regulation of this exopolysaccharide are provided.
Journal ArticleDOI
Cloning of genes controlling alginate biosynthesis from a mucoid cystic fibrosis isolate of Pseudomonas aeruginosa.
TL;DR: Mucoid strains of Pseudomonas aeruginosa isolated from the sputum of cystic fibrosis patients produce copious quantities of an exopolysaccharide known as alginic acid, which has been difficult to isolate individual structural gene mutants defective in alginate synthesis.
Journal ArticleDOI
Epidemiology of Infections Due to Pseudomonas aeruginosa
TL;DR: The reservoirs and modes of transmission for P. aeruginosa are reviewed along with recent studies aimed at the prevention of both colonization and infection by this organism.
References
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Journal ArticleDOI
Long-Term Study of One Hundred Five Patients with Cystic Fibrosis: Studies Made Over a Five- to Fourteen-Year Period
TL;DR: A system of clinical evaluation is introduced which can be used as a measuring device to compare one patient with the next in a study of survival beyond childhood of patients with cystic fibrosis.
Journal ArticleDOI
Untersuchungen über die O-Antigene von Pseudomonas aeruginosa
TL;DR: In this article, the authors found that in all the Stammen der Art gemeinsames antigen is not nachweisbar, nachwiesen werden konnen.
Journal ArticleDOI
An atypical Pseudomonas aeruginosa associated with cystic fibrosis of the pancreas
TL;DR: An atypical Pseudomonas aeruginosa has been isolated from the trancheobronchial tree of children with cystic fibrosis of the pancreas (C/F) and appears to be a highly mucoid variant of the PseUDomonas species in which the slime envelope can be precipitated by an ethanol-benzene mixture and is rendered difficult to dissolve in water.
Journal ArticleDOI
Comparison of some properties of pseudomonas aeruginosa isolated from infections in persons with and without cystic fibrosis.
TL;DR: Pseudomonas aeruginosa isolated from the respiratory tract of a group of patients diagnosed as having cystic fibrosis of the pancreas attained the ability to produce in its capsule a material which was insoluble in certain organic solvents, such as ethanol, which could be demonstrated to persist after sequential subcultures of this organism.
Journal ArticleDOI
The Bacterial Hemagglutination Test for the Demonstration of Antibodies to Enterobacteriaceae
TL;DR: Observations on the monovalent and polyvalent enterobacterial hemagglutination tests and the hemolytic modification of these tests are recorded here, and the potential usefulness of these methods for the diagnosis and epidemiological investigation of enterob bacterial diarrheal disease is documented.