Journal ArticleDOI
Serotonergic-cholinergic neurotransmitters’ function in brain during cadmium exposure in protein restricted rat
Reads0
Chats0
TLDR
Results indicate that the intensity of cadmium effect is more evident in discrete brain regions in protein restricted dietary condition than in the normal group, and the inhibitory action of Cd on both neurotransmitters has been discussed.Abstract:
Daily subcutaneous injection of cadmium chloride (0.3 mg/100g bw) for two weeks to normal and protein restricted (5% casein) rats shows significant decrease in 5-HT concentration in cerebellum, medulla oblongata-pons, hypothalamus, striatum-hippocampus, midbrain-thalamus-subthalamus, and cortex in both dietary regimens. No significant change occurs in concentration of ACh in cerebellum, but there is a significant increase in cortex, whereas significant decrease occurs in rest of the discrete regions of brain in both dietary conditions. Results also indicate that the intensity of cadmium effect is more evident in discrete brain regions in protein restricted dietary condition than in the normal group. The inhibitory action of Cd on both neurotransmitters has been discussed.read more
Citations
More filters
Journal ArticleDOI
Parkinsonism after acute cadmium poisoning
TL;DR: The case suggests that cadmium intoxication may damage the basal ganglia, resulting in parkinsonism, in a 64-year-old man who suffered from acute exposure to Cadmium, followed by multiple organ failure, and developed parkinsonian features three months after exposure.
Journal ArticleDOI
Cadmium effects on hypothalamic-pituitary-testicular axis in male rats.
TL;DR: Cadmium globally effects hypothalamic-pituitary-testicular axis function by acting at the three levels analyzed and that an interaction between cadmium exposure and age emerge is suggested.
Journal ArticleDOI
Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat.
TL;DR: It is suggested that cadmium exerts age-dependent effects on the hypothalamic-pituitary-testicular axis function, and a disruption of the regulatory mechanisms of the hypothalamus-pituitsary-gonadal axis emerges.
Journal ArticleDOI
Cadmium effects on hypothalamic activity and pituitary hormone secretion in the male.
TL;DR: The accumulative data indicates the existence of a disruption in the regulatory mechanisms of the hypothalamic-pituitary axis and the physiological significance of these effects remains to be elucidated.
Journal ArticleDOI
Effects of combined exposure to lead and cadmium on the hypothalamic-pituitary axis function in proestrous rats.
TL;DR: The data suggest that the metal accumulation disrupts the regulatory mechanisms of the hypothalamic-pituitary axis where the effects produced by the combined treatment of metals are not additive.
References
More filters
Book
Principles of Biochemistry
TL;DR: The third edition, coming ten years after the first, emphasizes both the flowering of biochemical research and the prodigious effort by busy teachers and scientists to keep up to date this popular text and reference.
Book
Methods of Biochemical Analysis
TL;DR: The Radiation Inactivation Method as a Tool to Study Structure-Function Relationships in Proteins Immunoassay with Electrochemical Detection and Theory and Newer Technology Assays for Superoxide Dismutase are studied.
Journal ArticleDOI
Biochemical Effects of Mercury, Cadmium, and Lead
B L Vallee,D D Ulmer +1 more
TL;DR: A review of the chemical and biochemical effects of mercury, acadmium and lead is presented and the means available to identify their biochemical sites of action are discussed.
Journal ArticleDOI
Central synaptic transmission--microelectrophoretic studies.
D R Curtis,J M Crawford +1 more