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Journal ArticleDOI

Serum levels of follicle stimulating hormone and luteinizing hormone and of plasma progesterone related to ovulation by corpus luteum biopsy.

01 Mar 1970-The Journal of Clinical Endocrinology and Metabolism (The Endocrine Society)-Vol. 30, Iss: 3, pp 396-399
TL;DR: LH, FSH and progesterone levels in blood were determined in 5 subjects at 8-hr intervals over a 5-day period prior to scheduled laparotomy, with a significant rise prior to ovulation and a plateau, or slight fall corresponding to the time of ovulation.
Abstract: LH, FSH and progesterone levels in blood were determined in 5 subjects at 8-hr intervals over a 5-day period prior to scheduled laparotomy. The laparotomy was planned for the early postovulatory phase. The time of ovulation was estimated by corpus luteum biopsy. The mean levels of LH showed a significant rise 24 hr prior to ovulation and peaked at 16 hr prior to ovulation. FSH showed a similar but less marked pattern. Plasma progesterone showed a significant rise 16 hr prior to ovulation, with a plateau, or slight fall corresponding to the time of ovulation.
Citations
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Journal ArticleDOI
TL;DR: Good correlations show that ultrasound measurements of follicular diameter are valuable in the assessment of follicle growth and development, and offers an additional technique for the study of ovarian function.

313 citations

Book ChapterDOI
TL;DR: Basic and clinical studies to discuss gonadotropins and their subunits conclude that specific alterations of the carbohydrate portion of the glycoprotein hormones result in both immunologic and biologic alterations, depending on the hormone in question.
Abstract: Publisher Summary This chapter presents some basic and clinical studies to discuss gonadotropins and their subunits. These studies conclude that specific alterations of the carbohydrate portion of the glycoprotein hormones result in both immunologic and biologic alterations, depending on the hormone in question. The immunologic behavior of human chorionic gonadotropin (hCG) is least affected by desialylation as compared to lutenizing hormone (LH) and follicle stimulating hormone (FSH). The glycoprotein hormones—LH, FSH, hCG, and thyroid-stimulating hormone (TSH)—share a common quaternary structure composed of essentially identical α-subunits. Both the placenta and pituitary contain an excess of free α-subunits, that implies that the mechanism of synthesis and secretion of the glycoprotein hormones from those organs can be similar. Significant clinical applications have resulted from the basic immunologic and biologic studies of the subunits of the glycoprotein hormones. Specifically, antisera to the subunits of the glycoprotein hormones are used as probes for studying the synthesis and secretion of free subunits from both the pituitary and placenta. The specific antisera to the β -subunit of hCG are used to screen a wide variety of patients with tumors ectopically secreting hCG. These reagents should prove useful for further delineation of control of synthesis and secretion of the gonadotropins for future investigators.

251 citations

Journal ArticleDOI
TL;DR: It is concluded that the transport of unfertilized ova in women is characterized by a period of retention in the ampulla, which lasts approximately 72 hours, followed by rapid transit through the isthmus and appearance of the ovum in the endometrial cavity around 80 hours after ovulation.

192 citations

Journal ArticleDOI
TL;DR: It is concluded that the time of ovulation can be identified clinically, without recourse to temperature measurement or more specialised tests.

185 citations

Journal ArticleDOI
TL;DR: The interval between the estrogen and LH peaks and ovulation in women, rhesus monkeys, and baboons was ascertained and Plasma progesterone levels were significantly increased prior to the LH peak in all three species.

173 citations