Serum Protein Profiling Reveals a Specific Upregulation of the Immunomodulatory Protein Progranulin in Coronavirus Disease 2019.
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...However, current research shows that induction of interferons in cells infected with SARS-CoV-2 is impaired [18, 20, 21]....
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2,190 citations
"Serum Protein Profiling Reveals a S..." refers methods in this paper
...The severity of illness was assessed using the Sequential Organ Failure Assessment (SOFA) score [9]....
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"Serum Protein Profiling Reveals a S..." refers background or methods in this paper
...In line with this, we observed a positive correlation of GRN with IL-6 abundance and disease severity in patients with COVID-19....
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...Patients with high GRN expression showed higher maximum serum creatinine and IL-6 levels as surrogate parameters for disease severity (Fig....
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...Transcriptional profiling of human airway epithelial cells revealed an upregulation of IL-6 and other pro-inflammatory cytokines but a repression of interferon I and III signaling after SARS-CoV-2 infection [18]....
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...However, increased levels of IL-6 have been described in numerous conditions including trauma, surgery, sepsis, respiratory failure, myocardial infarction, or post-resuscitation syndrome [8] and can be considered as a general indicator of disease severity....
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...The lack of Ac ce pte d M an us cri pt interferons is associated with a persistent blood viral load and an increase of TNF-α and IL-6 [26], suggesting that the diminished interferon response contributes to impaired virus elimination and disease progression in COVID-19....
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