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Open AccessJournal ArticleDOI

Seryl-tRNA in Mammalian Tissues: Chromatographic Differences in Brain and Liver and a Specific Response to the Codon, UGA

Dolph L. Hatfield, +1 more
- 01 Nov 1970 - 
- Vol. 67, Iss: 3, pp 1200-1206
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TLDR
A species of beef seryl-tRNA obtained by reversed phase column chromatography that responds specifically to the codon UGA was found and in addition, a species of rabbit and of chicken serially-tRNAs that recognizes U GA was found.
Abstract
Differences in the elution profiles of seryl-tRNAs of beef and of rabbit liver and brain were observed. A species of beef seryl-tRNA obtained by reversed phase column chromatography that responds specifically to the codon UGA was found. In addition, a species of rabbit and of chicken seryl-tRNA that recognizes UGA was found.

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Selenoproteins: molecular pathways and physiological roles.

TL;DR: Current knowledge about how these unique proteins perform their functions at the molecular level is discussed and new insights into the roles that selenoproteins play in human health are highlighted.
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Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

TL;DR: The role of GPx-1 in cancer and cardiovascular disease is discussed and potential future therapies to harness the beneficial effects of this ubiquitous antioxidant enzyme are speculates.
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How selenium has altered our understanding of the genetic code.

TL;DR: While the fundamental mechanism of Sec insertion in these organisms appears to be similar, recent studies suggest that mammals evolved additional components that allow incorporation of multiple Secs into a single protein and provide stringent regulation of Sec biosynthesis.
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Identification of a selenocysteyl-tRNA(Ser) in mammalian cells that recognizes the nonsense codon, UGA.

TL;DR: It is proposed that a metabolic pathway for selenocysteine synthesis in mammalian cells is the conversion of seryl-tRNA(Ser) via phosphoseryl-t RNA(Ser), which recognizes UGA but not any of the serine codons.
Journal ArticleDOI

The selenium to selenoprotein pathway in eukaryotes: more molecular partners than anticipated.

TL;DR: The amino acid selenocysteine is the major biological form of the trace element selenium and is co-translationally incorporated in selenoproteins in eukaryotes.
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