SET for life: biochemical activities and biological functions of SET domain-containing proteins
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TLDR
The most recent findings on the biological functions of the major families of SET domain-containing proteins catalyzing the methylation of histones 3 on lysines 4, 9, 27, and 36 as well as candidates that have been reported to regulate non-histone substrates are summarized.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2013-12-01 and is currently open access. It has received 253 citations till now. The article focuses on the topics: Histone lysine methylation & Histone methyltransferase.read more
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Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
TL;DR: This review describes those enzymes and their inhibitors that have already reached the first stages of clinical trials in cancer therapy, namely the histone methyltransferases DOT1L and EZH2 as well as the demethylase LSD1.
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Comprehensive Catalog of Currently Documented Histone Modifications
Yingming Zhao,Benjamin A. Garcia +1 more
TL;DR: This work catalogs histone PTMs under two classes: first, those whose functions have been fairly well studied and, second, those PTMs that have been more recently identified but whose functions remain unclear.
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Enhancer biology and enhanceropathies
Edwin R. Smith,Ali Shilatifard +1 more
TL;DR: Genome-wide analyses have revealed chromatin signatures of enhancers, and enhancer signatures have been used to describe the transitions of these regulatory elements from inactive to primed and from activated to decommissioned states during development.
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Epigenetic modifications of histones in cancer
Zibo Zhao,Ali Shilatifard +1 more
TL;DR: The enzymatic machineries and modifications that are involved in cancer development and progression are reviewed, and how to apply currently available small molecule inhibitors for histone modifiers as tool compounds to study the functional significance of histone modifications and their clinical implications is reviewed.
Journal ArticleDOI
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells
Maia Vinogradova,Victor S. Gehling,Amy Gustafson,Shilpi Arora,Charles Tindell,Catherine Wilson,Kaylyn E. Williamson,Gulfem D. Guler,Pranoti Gangurde,Wanda Manieri,Jennifer Busby,E. Megan Flynn,Fei Lan,Hyojin Kim,Shobu Odate,Andrea G. Cochran,Yichin Liu,Matthew Wongchenko,Yibin Yang,Tommy K. Cheung,Tobias M. Maile,Ted Lau,Michael R. Costa,Ganapati V. Hegde,Erica L. Jackson,Robert M. Pitti,David Arnott,Christopher M. Bailey,Steve Bellon,Richard T. Cummings,Brian K. Albrecht,Jean-Christophe Harmange,James R. Kiefer,Patrick Trojer,Marie Classon +34 more
TL;DR: Findings show that pretreatment of cancer cells with a KDM5-specific inhibitor results in the ablation of a subpopulation of cancers cells that can serve as the founders for therapeutic relapse.
References
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Journal ArticleDOI
High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
Journal ArticleDOI
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
John L. Rinn,Michael Kertesz,Jordon K. Wang,Sharon L. Squazzo,Xiao Xu,Samantha A. Brugmann,L. Henry Goodnough,Jill A. Helms,Peggy J. Farnham,Eran Segal,Howard Y. Chang +10 more
TL;DR: The transcriptional landscape of the four human HOX loci is characterized at five base pair resolution in 11 anatomic sites and 231 HOX ncRNAs are identified that extend known transcribed regions by more than 30 kilobases, suggesting transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance.
Journal ArticleDOI
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.
Nathaniel D. Heintzman,Rhona K. Stuart,Gary C. Hon,Yutao Fu,Christina W. Ching,R. David Hawkins,Leah O. Barrera,Sara Van Calcar,Chunxu Qu,Keith A. Ching,Wei Wang,Zhiping Weng,Roland Green,Gregory E. Crawford,Bing Ren +14 more
TL;DR: Insight is given into the connections between chromatin modifications and transcriptional regulatory activity and a novel functional enhancer for the carnitine transporter SLC22A5 (OCTN2) is uncovered, providing a new tool for the functional annotation of the human genome.
Journal ArticleDOI
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Miao-Chih Tsai,Ohad Manor,Yue Wan,Nima Mosammaparast,Jordon K. Wang,Fei Lan,Yang Shi,Eran Segal,Howard Y. Chang +8 more
TL;DR: The results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.
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