Severe fever with thrombocytopenia syndrome, South Korea, 2012.
Kye-Hyung Kim,Jongyoun Yi,Gayeon Kim,Su Jin Choi,Kang Il Jun,Nak Hyun Kim,Pyoeng Gyun Choe,Nam-Joong Kim,Jong Koo Lee,Myoung Don Oh +9 more
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TLDR
A retrospectively identified fatal case of severe fever with thrombocytopenia syndrome in South Korea from 2012 was identified and the isolate was closely related to SFTS virus strains from China and Japan.Abstract:
We report a retrospectively identified fatal case of severe fever with thrombocytopenia syndrome (SFTS) in South Korea from 2012. SFTS virus was isolated from the stored blood of the patient. Phylogenetic analysis revealed this isolate was closely related to SFTS virus strains from China and Japan.read more
Citations
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Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase
TL;DR: Favipiravir is an anti-viral agent that selectively and potently inhibits the RNA-dependent RNA polymerase (RdRp) of RNA viruses, which is effective against a wide range of types and subtypes of influenza viruses, including strains resistant to existing anti-influenza drugs.
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Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis
TL;DR: Information is provided on the molecular characteristics and ecology of this emerging tick-borne virus and the epidemiology, clinical signs, pathogenesis, diagnosis, treatment, and prevention of human infection with SFTSV.
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Haemaphysalis longicornis Ticks as Reservoir and Vector of Severe Fever with Thrombocytopenia Syndrome Virus in China
Li Mei Luo,Li Zhao,Hongling Wen,Zhen Tang Zhang,Jian Wei Liu,Li Zhu Fang,Zai Feng Xue,Dong Qiang Ma,Xiao Shuang Zhang,Shu Jun Ding,Xiao-Ying Lei,Xue Jie Yu +11 more
TL;DR: Transstadial and transovarial virus transmission occur among ticks, and transmission to mice can occur through a tick bite.
Journal ArticleDOI
Emerging Tick-Borne Diseases.
TL;DR: The most significant pathogens that infect humans as well as the epidemiology, clinical features, diagnosis, and treatment of diseases that they cause are emphasized.
Journal ArticleDOI
Emerging tick-borne infections in mainland China: an increasing public health threat
Li Qun Fang,Kun Liu,Xin Lou Li,Song Liang,Yang Yang,Hong Wu Yao,Ruo-Xi Sun,Ye Sun,Wan Jun Chen,Shu Qing Zuo,Mai Juan Ma,Hao Li,Jia-Fu Jiang,Wei Liu,X. Frank Yang,Gregory C. Gray,Peter J. Krause,Wu-Chun Cao +17 more
TL;DR: This Review has mapped the geographical distributions of human cases of infection in mainland China and expects that more novel tick-borne infections in ticks and animals will be identified and additional emergingtick-borne diseases in human beings will be discovered.
References
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Journal ArticleDOI
Fever with thrombocytopenia associated with a novel bunyavirus in China.
Xue Jie Yu,Mi Fang Liang,Shou Yin Zhang,Yan Liu,Jiandong Li,Yu Lan Sun,Lihong Zhang,Quan Fu Zhang,Vsevolod L. Popov,Chuan Li,Jing Qu,Qun Li,Yan Ping Zhang,Rong Hai,Wei Wu,Qin Wang,Fa Xian Zhan,Xian Jun Wang,Biao Kan,Shi Wen Wang,Kang Lin Wan,Huai Qi Jing,Jin Xin Lu,Wen Wu Yin,Hang Zhou,Xu Hua Guan,Jia Fa Liu,Zhen Qiang Bi,Guohua Liu,Jun Ren,Hua Wang,Zhuo Zhao,Jing Dong Song,Jin Rong He,Tao Wan,Jing Shan Zhang,Xiu Ping Fu,Li Na Sun,Xiao-Ping Dong,Zi Jian Feng,Wei Zhong Yang,Tao Hong,Yu Zhang,David H. Walker,Yu Wang,Dexin Li +45 more
TL;DR: A novel phlebovirus was identified in patients with a life-threatening illness associated with fever and thrombocytopenia in China using enzyme-linked immunosorbent assay, indirect immunofluorescence assay, and neutralization testing to analyze the level of virus-specific antibody in patients' serum samples.
Fever with thrombocytopenia associated with a novel bunyavirus in China
Abstract: BACKGROUND
Heightened surveillance of acute febrile illness in China since 2009 has led to the identification of a severe fever with thrombocytopenia syndrome (SFTS) with an unknown cause. Infection with Anaplasma phagocytophilum has been suggested as a cause, but the pathogen has not been detected in most patients on laboratory testing.
METHODS
We obtained blood samples from patients with the case definition of SFTS in six provinces in China. The blood samples were used to isolate the causal pathogen by inoculation of cell culture and for detection of viral RNA on polymerase-chain-reaction assay. The pathogen was characterized on electron microscopy and nucleic acid sequencing. We used enzyme-linked immunosorbent assay, indirect immunofluorescence assay, and neutralization testing to analyze the level of virus-specific antibody in patients' serum samples.
RESULTS
We isolated a novel virus, designated SFTS bunyavirus, from patients who presented with fever, thrombocytopenia, leukocytopenia, and multiorgan dysfunction. RNA sequence analysis revealed that the virus was a newly identified member of the genus phlebovirus in the Bunyaviridae family. Electron-microscopical examination revealed virions with the morphologic characteristics of a bunyavirus. The presence of the virus was confirmed in 171 patients with SFTS from six provinces by detection of viral RNA, specific antibodies to the virus in blood, or both. Serologic assays showed a virus-specific immune response in all 35 pairs of serum samples collected from patients during the acute and convalescent phases of the illness.
CONCLUSIONS
A novel phlebovirus was identified in patients with a life-threatening illness associated with fever and thrombocytopenia in China. (Funded by the China Mega-Project for Infectious Diseases and others.).
Journal ArticleDOI
Person-to-Person Transmission of Severe Fever with Thrombocytopenia Syndrome Virus
Yan Liu,Qun Li,Wanfu Hu,Jiabin Wu,Yubi Wang,Ling Mei,David H. Walker,Jun Ren,Yu Wang,Xue Jie Yu +9 more
TL;DR: It is concluded that SFTSV can be transmitted from person to person through contacting patient's blood.
Journal ArticleDOI
Clinical Progress and Risk Factors for Death in Severe Fever with Thrombocytopenia Syndrome Patients
Zhong-Tao Gai,Ying Zhang,Mifang Liang,Cong Jin,Shuo Zhang,Cheng-Bao Zhu,Chuan Li,Xiao-Ying Li,Quanfu Zhang,Peng-Fei Bian,Li-Hua Zhang,Bin Wang,Na Zhou,Jin-Xia Liu,Xiu-Guang Song,Anqiang Xu,Zhenqiang Bi,Shi-Jun Chen,Dexin Li +18 more
TL;DR: A period of 7-13 days after the onset of illness as the critical stage in SFTS progression is identified, which may indicate that disease conditions will worsen and lead to death.
Journal ArticleDOI
Severe Fever with Thrombocytopenia Syndrome Virus among Domesticated Animals, China
Guoyu Niu,Jiandong Li,Mifang Liang,Xiaolin Jiang,Mei Jiang,Haiying Yin,Zhidian Wang,Chuan Li,Quanfu Zhang,Cong Jin,Xianjun Wang,Shujun Ding,Zheng Xing,Shiwen Wang,Zhenqiang Bi,Dexin Li +15 more
TL;DR: It is demonstrated that natural infections of SFTSV occur in several domesticated animal hosts in disease-endemic areas and that the virus has a wide host range.
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