Sex differences in social interaction behavior following social defeat stress in the monogamous California mouse (Peromyscus californicus).
Brian C. Trainor,Michael C. Pride,Rosalina Villalon Landeros,Nicholas W. Knoblauch,Elizabeth Y. Takahashi,Andrea L. Silva,Katie K. Crean +6 more
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The data suggest that California mice could be a useful model for studying sex differences in behavioral responses to stress, particularly in neurobiological mechanisms that are involved with the regulation of social behavior.Abstract:
Stressful life experiences are known to be a precipitating factor for many mental disorders. The social defeat model induces behavioral responses in rodents (e.g. reduced social interaction) that are similar to behavioral patterns associated with mood disorders. The model has contributed to the discovery of novel mechanisms regulating behavioral responses to stress, but its utility has been largely limited to males. This is disadvantageous because most mood disorders have a higher incidence in women versus men. Male and female California mice (Peromyscus californicus) aggressively defend territories, which allowed us to observe the effects of social defeat in both sexes. In two experiments, mice were exposed to three social defeat or control episodes. Mice were then behaviorally phenotyped, and indirect markers of brain activity and corticosterone responses to a novel social stimulus were assessed. Sex differences in behavioral responses to social stress were long lasting (4 wks). Social defeat reduced social interaction responses in females but not males. In females, social defeat induced an increase in the number of phosphorylated CREB positive cells in the nucleus accumbens shell after exposure to a novel social stimulus. This effect of defeat was not observed in males. The effects of defeat in females were limited to social contexts, as there were no differences in exploratory behavior in the open field or light-dark box test. These data suggest that California mice could be a useful model for studying sex differences in behavioral responses to stress, particularly in neurobiological mechanisms that are involved with the regulation of social behavior.read more
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The brain reward circuitry in mood disorders
Scott J. Russo,Eric J. Nestler +1 more
TL;DR: This Review synthesizes recent data from human and rodent studies from which emerges a circuit-level framework for understanding reward deficits in depression, and discusses some of the molecular and cellular underpinnings of this framework, ranging from adaptations in glutamatergic synapses and neurotrophic factors to transcriptional and epigenetic mechanisms.
Journal ArticleDOI
What's wrong with my mouse: Behavioral phenotyping of transgenic and knockout mice, J. Crawley. Wiley-Interscience, Hoboken, NJ (2007), 523 pages, $99.95
Journal ArticleDOI
Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior
Sophie Leclercq,Firoz Mian,Andrew M. Stanisz,Laure B. Bindels,Emmanuel Cambier,Hila Ben-Amram,Omry Koren,Paul Forsythe,Paul Forsythe,John Bienenstock,John Bienenstock +10 more
TL;DR: Penicillin has lasting effects in both sexes on gut microbiota, increases cytokine expression in frontal cortex, modifies blood–brain barrier integrity and alters behaviour, and warrants further studies on the potential role of early-life antibiotic use in the development of neuropsychiatric disorders.
Journal ArticleDOI
Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress
Georgia E. Hodes,Madeline L. Pfau,Immanuel Purushothaman,H. Francisca Ahn,Sam A. Golden,Daniel J. Christoffel,Jane Magida,Anna Brancato,Aki Takahashi,Meghan E. Flanigan,Caroline Menard,Hossein Aleyasin,Ja Wook Koo,Zachary S. Lorsch,Jian Feng,Mitra Heshmati,Minghui Wang,Gustavo Turecki,Rachel L. Neve,Bin Zhang,Li Shen,Eric J. Nestler,Scott J. Russo +22 more
TL;DR: It is reported that exposure to subchronic variable stress (SCVS) induces depression-associated behaviors in female mice, whereas males are resilient as they do not develop these behavioral abnormalities, and transcriptional analysis of nucleus accumbens revealed markedly different patterns of stress regulation of gene expression between the sexes.
Journal ArticleDOI
Erratum: The brain reward circuitry in mood disorders
Scott J. Russo,Eric J. Nestler +1 more
TL;DR: In table 2 of this article, the arrow indicating decreased susceptibility as an effect of ΔFOSB in depression models (third column) was incorrectly displayed as pointing upwards.
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