Shaping proteostasis at the cellular, tissue, and organismal level.
Citations
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Cites background from "Shaping proteostasis at the cellula..."
...In metazoans the stress-response pathways additionally underlie cell nonautonomous regulation, allowing coordination within and between tissues and organs (Taylor et al., 2014; Sala et al., 2017)....
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...…(Uhlén et al., 2015), tissue-specific proteomes and regulatory programs imply that there must be a marked heterogeneity in aspects of proteostasis across diverse cell types, suggesting the existence of tissue-specific PNs (Sala et al., 2017) with differing contributions of the three branches....
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...However, in metazoans (Guisbert et al., 2013), especially in complex mammalian systems (Uhlén et al., 2015), tissue-specific proteomes and regulatory programs imply that there must be a marked heterogeneity in aspects of proteostasis across diverse cell types, suggesting the existence of tissue-specific PNs (Sala et al., 2017) with differing contributions of the three branches....
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..., 2015), tissue-specific proteomes and regulatory programs imply that there must be a marked heterogeneity in aspects of proteostasis across diverse cell types, suggesting the existence of tissue-specific PNs (Sala et al., 2017) with differing contributions of the three branches....
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...The repertoire of human chaperones (the “chaperome”) contains ∼330 members of several functionally distinct gene families, which cater to diverse substrate clients (Brehme et al., 2014; Sala et al., 2017; Fig....
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238 citations
169 citations
Cites background from "Shaping proteostasis at the cellula..."
...In addition to accumulated evidence regarding activity-dependent regulation of proteostasis in mammals, studies in model organisms provide fundamental insights into the mechanisms of proteostasis at different scales: cellular, tissue, and systemic (Sala et al., 2017)....
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...The proteostasis network regulates protein synthesis, folding, transport, and degradation to maintain proteome integrity and limit the accumulation of protein aggregates (Balch et al., 2008; Sala et al., 2017)....
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111 citations
Cites background from "Shaping proteostasis at the cellula..."
...Moreover, in most cases specific cell types and tissues are exclusively or preferentially affected (Fu et al. 2018), suggesting an underlying heterogeneity between cell types in proteostasis capacity and the ability to respond to proteotoxic stress (Sala et al. 2017)....
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References
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"Shaping proteostasis at the cellula..." refers background in this paper
...Both XBP1 and ATF6 induce prosurvival pathways that up-regulate genes involved in protein folding, ER-associated protein degradation, and lipid metabolism (Walter and Ron, 2011)....
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3,557 citations
"Shaping proteostasis at the cellula..." refers background in this paper
...Enhanced proteostasis and extended lifespan in animals devoid of a germline rely on multiple transcription factors, including DAF16, PHA4, and SKN1, in addition to HSF1 (Lin et al., 2001; Lapierre et al., 2011; Steinbaugh et al., 2015)....
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...elegans these functions are performed by SKN1 (Itoh et al., 1997; An and Blackwell, 2003; Radhakrishnan et al., 2010)....
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...The OxR has two branches, which are mediated by the stress-responsive transcription factors NRF1/NFE2L1 and NRF2/NFE2L2 in mammals, whereas in C. elegans these functions are performed by SKN1 (Itoh et al., 1997; An and Blackwell, 2003; Radhakrishnan et al., 2010)....
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...Conversely, key UPRER signaling factors are involved in the activation of SKN1 during oxidative stress....
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...Notably, these two SKN1-mediated responses as part of the UPRER and OxR have distinct but overlapping targets (Glover-Cutter et al., 2013)....
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3,174 citations
"Shaping proteostasis at the cellula..." refers background in this paper
...The muscle-specific ubiquitin ligases MAFbx/ atrogin-1 and MuRF family members are induced and mediate breakdown of various muscle proteins during atrophic conditions, further demonstrating the need for specific PN activities in this tissue (Bodine et al., 2001; Gomes et al., 2001)....
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