Shared genetic etiology between alcohol dependence and major depressive disorder.
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Cites background from "Shared genetic etiology between alc..."
...Indeed, genetic studies indicate significant shared heritability of AUD and depression (5)....
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References
6,809 citations
"Shared genetic etiology between alc..." refers methods in this paper
...We calculated MDD-PRS in the GESGA sample using the PGC-MDD2 results following previously published methods (Ripke et al., 2014)....
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4,573 citations
"Shared genetic etiology between alc..." refers methods in this paper
...The proportion of variance in case–control status explained by MDD-PRS was assessed by Nagelkerke’s pseudo R(2) derived from the difference between the full regression model (PRS+ covariates) and the null model (only covariates) (Purcell et al., 2009; Power et al., 2015)....
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...The proportion of variance in case–control status explained by MDD-PRS was assessed by Nagelkerke’s pseudo R2 derived from the difference between the full regression model (PRS+ covariates) and the null model (only covariates) (Purcell et al., 2009; Power et al., 2015)....
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...The polygenic risk score (PRS) approach is a statistical method that enables the assessment of additive effects of multiple common genome-wide genetic variations on risk for a disorder, and is well suited to characterize shared genetic etiology of complex disorders (Purcell et al., 2009)....
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2,993 citations
"Shared genetic etiology between alc..." refers background in this paper
...Another approach which can be utilized with larger target samples is LD score regression to estimate genetic correlation across diseases and subgroups (Bulik-Sullivan et al., 2015)....
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1,898 citations
1,686 citations
"Shared genetic etiology between alc..." refers background in this paper
...Although not possible here owing to the relatively small size of the target sample, the application of techniques to dissect pleiotropy, such as BUHMBOX (Han et al., 2016) or Mendelian randomization (Davey Smith and Hemani, 2014), will lead to better understanding of this disease comorbidity....
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