Short‐term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance
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1,362 citations
Cites background from "Short‐term sprint interval versus t..."
...As little as six sessions of this type of training, totalling ∼15 min of all out cycle exercise over 2 weeks, increased skeletal muscle oxidative capacity as reflected by the maximal activity and/or protein content of mitochondrial enzymes (Burgomaster et al. 2005; Gibala et al. 2006)....
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...Both types of low-volume HIT protocols are also effective for improving functional performance, as shown by cycling time trials that resemble normal athletic competition (Gibala et al. 2006; Little et al. 2010b)....
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...1), other endurance-like adaptations have been documented after several weeks of low-volume HIT including an increased resting glycogen content, a reduced rate of glycogen utilization and lactate production during matched-work exercise, an increased capacity for whole-body and skeletal muscle lipid oxidation, enhanced peripheral vascular structure and function, improved exercise performance as measured by time-to-exhaustion tests or time trials and increased maximal oxygen uptake (Burgomaster et al. 2005, 2008; Gibala et al. 2006; Rakobowchuk et al. 2008)....
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...…whole-body and skeletal muscle lipid oxidation, enhanced peripheral vascular structure and function, improved exercise performance as measured by time-to-exhaustion tests or time trials and increased maximal oxygen uptake (Burgomaster et al. 2005, 2008; Gibala et al. 2006; Rakobowchuk et al. 2008)....
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1,151 citations
Cites background or methods or result from "Short‐term sprint interval versus t..."
...The present results confirm and extend our recent findings (Gibala et al. 2006a) of similar increases in muscle oxidative capacity and volitional exercise performance after six sessions of SIT or ET over 2 weeks....
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...The SIT protocol was modelled on previous work in our laboratory and consisted of four to six 30 s ‘all out’ cycling tasks performed three times per week for 6 weeks (Burgomaster et al. 2006; Gibala et al. 2006a)....
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...…numerous studies have shown that brief, repeated sessions of ‘all out’ high-intensity or sprint-type interval training (SIT) elicits changes in skeletal muscle energy metabolism that resemble traditional endurance training (ET) (Henriksson & Reitman, 1976; Saltin et al. 1976; Gibala et al. 2006a)....
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...Consistent with this interpretation, in a preliminary report we (Gibala et al. 2006b) showed activation of AMPK and p38 MAPK in response to an acute session of Wingate-based exercise training....
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...It is interesting that the relative increase in maximal activity of CS after 6 weeks in the present study (∼25% in both groups) was similar to that observed for COX after 2 weeks in our previous study (Gibala et al. 2006a)....
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918 citations
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Cites background or methods from "Short‐term sprint interval versus t..."
...As little as six sessions of low-volume HIT over 2 wk increases skeletal muscle mitochondrial capacity (8), which may be of clinical relevance for T2D given that reduced content (22) or biogenesis (18) of mitochondria have been implicated in insulin resistance and T2D....
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...Given the potency of low-volume HIT to induce mitochondrial biogenesis in young, healthy subjects (8, 16), we hypothesized that HIT might also increase mitochondrial capacity in skeletal muscle of individuals with T2D....
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...4) supplemented with protease inhibitors (Complete Mini, Roche Applied Science, Laval, PQ, Canada) and used to determine the maximal activity of citrate synthase (CS) as we previously described (8, 16)....
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...We (8, 14, 16) and others (1, 21) have shown that HIT elicits physiological remodeling comparable to moderate-intensity continuous training in healthy adults, despite a substantially lower time commitment and reduced total exercise volume....
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...Subjects returned to the laboratory 2 days later for removal of the CGM device and collection of a resting skeletal muscle biopsy sample as we previously described (8)....
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References
289,852 citations
"Short‐term sprint interval versus t..." refers methods in this paper
...Protein content of the muscle homogenate was determined by the method of Lowry et al. (1951) and enzyme activity was calculated in mol (kg protein)−1 h−1....
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139,407 citations
1,997 citations
"Short‐term sprint interval versus t..." refers background in this paper
...…to the improved respiratory control sensitivity that results from an increase in mitochondrial density, as reflected by changes in the maximal activity or protein content of enzymes in the tricarboxylic acid cycle and electron transport chain (Saltin & Gollnick, 1983; Holloszy & Coyle, 1984)....
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...One of the most prominent adaptations to training is a change in skeletal muscle substrate metabolism (Holloszy & Coyle, 1984)....
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895 citations
"Short‐term sprint interval versus t..." refers background in this paper
...’ With regards to human muscle, several groups have described changes in the expression of PGC-1α and other metabolic transcriptional co-activators and transcription factors after acute exercise (Pilegaard et al. 2003; Russell et al. 2005; Coffey et al. 2006); however, no studies have directly compared adaptations induced by different types of exercise training....
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...…have described changes in the expression of PGC-1α and other metabolic transcriptional co-activators and transcription factors after acute exercise (Pilegaard et al. 2003; Russell et al. 2005; Coffey et al. 2006); however, no studies have directly compared adaptations induced by different types…...
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891 citations
"Short‐term sprint interval versus t..." refers background in this paper
...…to the improved respiratory control sensitivity that results from an increase in mitochondrial density, as reflected by changes in the maximal activity or protein content of enzymes in the tricarboxylic acid cycle and electron transport chain (Saltin & Gollnick, 1983; Holloszy & Coyle, 1984)....
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