Journal ArticleDOI
Side Effects of Corticosteroid Therapy: Psychiatric Aspects
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TLDR
While dosage may be correlated to the risk of developing mental disturbances, neither dosage nor duration of treatment seems to affect the time of onset, duration, severity, or type of mental disturbances.Abstract:
• We reviewed the literature to determine the characteristics of corticosteroid-induced mental disturbances. We conclude that (1) while dosage may be correlated to the risk of developing mental disturbances, neither dosage nor duration of treatment seems to affect the time of onset, duration, severity, or type of mental disturbances; (2) euphoria, depression, and psychotic reactions are the common manifestations of corticosteroidinduced mental disturbances; (3) females seem to be more prone to these disturbances than males; (4) patients with past mental illness are not necessarily predisposed to such disturbances; and (5) corticosteroid-induced mental disturbances are usually reversible on dose reduction or discontinuation of the drug. At present there are no simple models to explain the psychotic reactions, anxiety, or agitation seen in corticosteroidinduced mental disturbances.read more
Citations
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The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition.
TL;DR: The cases that led to the diagnosis of glucocorticoid-induced 'steroid psychosis' in human populations are summarized and it is suggested that some of the 'age-related memory impairments' observed in the literature could be partly due to increased stress reactivity in older adults to the environmental context of testing.
Journal ArticleDOI
Insomnia in the Context of Cancer: A Review of a Neglected Problem
Josée Savard,Charles M. Morin +1 more
TL;DR: It is argued that psychologic interventions are the treatment of choice for sleep disturbances in the context of cancer, especially when it has reached a chronic course.
Journal ArticleDOI
PSYCHONEUROENDOCRINOLOGY OF DEPRESSION: Hypothalamic-Pituitary-Adrenal Axis
TL;DR: Functional assessment of the HPA axis is thought to provide a window into central nervous system operation that may be of diagnostic value in this and other affective disorders regardless of whether CRF and glucocorticoids are directly involved in the origin of major depression or merely exacerbate the consequences of other primary defects.
Journal ArticleDOI
Basal cortisol levels and cognitive deficits in human aging
Sonia J. Lupien,AndréRoch Lecours,Isabelle Lussier,G. Schwartz,N. P. V. Nair,Michael J. Meaney +5 more
TL;DR: Impaired cognitive performance was associated with recent evidence of hypothalamic-pituitary-adrenal (HPA) dysregulation and elevated basal cortisol levels and was consistent with recent animal studies showing the existence of subpopulations of aged rats that differ in HPA activity and cognitive performance.
Journal ArticleDOI
Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats
Shari R. Bodnoff,Aaron G. Humphreys,Jennifer C. Lehman,David M. Diamond,Gregory M. Rose,Michael J. Meaney +5 more
TL;DR: Elevated glucocorticoid levels mediate the effects of stress on spatial memory in older animals, suggesting that elevation of corticosterone levels mediates the effect of stress in animals that had been previously adrenalectomized.
References
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Journal ArticleDOI
Pemphigus: a 20-year review of 107 patients treated with corticosteroids
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