Journal ArticleDOI
Siderophore Biosynthesis Governs the Virulence of Uropathogenic Escherichia coli by Coordinately Modulating the Differential Metabolism
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TLDR
It is demonstrated that siderophore biosynthesis coordinately modulated the differential metabolomes and thus may indicate novel targets for virulence-based diagnosis, therapeutics, and drug development related to urinary tract infections.Abstract:
Urinary tract infections impose substantial health burdens on women worldwide. Urinary tract infections often incur a high risk of recurrence and antibiotic resistance, and uropathogenic E. coli accounts for approximately 80% of clinically acquired cases. The diagnosis of, treatment of, and drug development for urinary tract infections remain substantial challenges due to the complex pathogenesis of this condition. The clinically isolated UPEC 83972 strain was found to produce four siderophores: yersiniabactin, aerobactin, salmochelin, and enterobactin. The biosyntheses of some of these siderophores implies that the virulence of UPEC is mediated via the targeting of primary metabolism. However, the differential modulatory roles of siderophore biosyntheses on the differential metabolomes of UPEC and non-UPEC strains remain incompletely understood. In the present study, we sought to investigate how the differential metabolomes can be used to distinguish UPEC from non-UPEC strains and to determine the associ...read more
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Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation.
TL;DR: Recent advances in understanding the interaction between Lcn2 and iron are summarized, whereas both beneficial and detrimental functions have been documented in neurodegenerative diseases, metabolic syndrome, renal disorders, skin disorders, and cancer.
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Metabolic adaptations of Uropathogenic E. coli in the urinary tract
TL;DR: The nutritional and metabolic requirements for UPEC infection in these environments are described, and particular metabolic responses and adaptations of UPEC that appear to be essential for survival in the urinary tract are focused on.
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Siderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infection
TL;DR: This report highlights the untapped resource of bacteria-specific small molecules as potential vaccine antigens and provides a proof of principle for incorporating these compounds into multicomponent vaccines for the prevention of bacterial infections.
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Pathophysiology, treatment, and prevention of catheter-associated urinary tract infection
TL;DR: The epidemiology, pathogen prevalence, differential mechanisms used by uropathogens, and treatment and prevention of uncomplicated UTI and CAUTI are reviewed.
References
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