Signaling networks of Rho GTPases in cell motility
Samer Hanna,Mirvat El-Sibai +1 more
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TLDR
The upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis are summarized.About:
This article is published in Cellular Signalling.The article was published on 2013-10-01 and is currently open access. It has received 221 citations till now. The article focuses on the topics: GTPase & Upstream and downstream (transduction).read more
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Stress granules and cell signaling: more than just a passing phase?
TL;DR: It is argued that stress granules constitute RNA-centric signaling hubs analogous to classical multiprotein signaling domains such as transmembrane receptor complexes and may require a cytosolic phase transition facilitated by intrinsically disordered, aggregation-prone protein regions shared by RNA-binding and signaling proteins.
PatentDOI
Recurrent mutations in epigenetic regulators, rhoa and fyn kinase in peripheral t-cell lymphomas
TL;DR: In this paper, the authors identified highly recurrent epigenetic factor mutations in TET2, DN-MT3A and IDH2 as well as a new highly prevalent RHOA p.Gly17Val (NM_001664) mutation present in 22/35 (67%) of angioimmunoblastic T-cell lymphomas (AITL) and in 8/44 (18%) not otherwise specified PTCL (PTCL NOS) samples.
Journal ArticleDOI
Nongenomic actions of thyroid hormone.
TL;DR: Nongenomic actions expand the repertoire of cellular events controlled by thyroid hormone and can modulate TR-dependent nuclear events.
Journal ArticleDOI
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton
Hai Hu,Ashish Juvekar,Costas A. Lyssiotis,Evan C. Lien,John G. Albeck,Doogie Oh,Gopal Varma,Yin P Hung,Soumya Ullas,Josh Lauring,Pankaj Seth,Mark R. Lundquist,Dean R. Tolan,Aaron K. Grant,Daniel J. Needleman,John M. Asara,Lewis C. Cantley,Gerburg M. Wulf +17 more
TL;DR: A master regulatory function of PI3K is pointed toward that integrates an epithelial cell's metabolism and its form, shape, and function, coordinating glycolysis with the energy-intensive dynamics of actin remodeling.
References
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Molecular Cell Biology
TL;DR: Molecular cell biology, Molecular cell biology , مرکز فناوری اطلاعات و اصاع رسانی, کδاوρزی
Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.
Anne J. Ridley,Alan Hall +1 more
TL;DR: Rho, a ras-related GTP-binding protein, rapidly stimulated stress fiber and focal adhesion formation when microinjected into serum-starved Swiss 3T3 cells, implying that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors.
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Cell Migration: A Physically Integrated Molecular Process
TL;DR: The authors are grateful for financial support from the National Institutes of Health (grants GM23244 and GM53905), and to very helpful comments on the manuscript from Elliot Elson, Vlodya Gelfand, Paul Matsudaira, Julie Theriot, and Sally Zigmond.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.