Significance of Circulating Tumor Cells Detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer.
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Cites methods from "Significance of Circulating Tumor C..."
...Once detected, enumeration and molecular characterization of CTCs have been applied to prognostic classifications of breast, prostate, and colon cancers (3), and to predictive markers of targeted drug therapy in lung cancer (4)....
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Cites background from "Significance of Circulating Tumor C..."
...Multiple studies have demonstrated that elevated CTC counts indicate a poor prognosis for metastatic breast, prostate, colorectal, and lung cancer patients (Cristofanilli et al., 2005; Smerage et al., 2014; de Bono et al., 2008; Cohen et al., 2008; Miller et al., 2010; Krebs et al., 2011)....
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389 citations
References
4,319 citations
"Significance of Circulating Tumor C..." refers background in this paper
...Over the succeeding one hundred and forty years, cancer research has indeed demonstrated the critical role circulating tumor cells play in the metastatic spread of carcinomas [2]....
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4,244 citations
"Significance of Circulating Tumor C..." refers background in this paper
...In both univariate and multivariate analysis CTC levels at all time points were significantly associated with overall survival [10, 13, 15]....
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2,343 citations
"Significance of Circulating Tumor C..." refers background or methods in this paper
...Accuracy, precision, linearity, and reproducibility of the CellSearch have been described elsewhere [17]....
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...5 mL of blood containing ∼ 5 × 10(7) leukocytes and 4 × 10(10) erythrocytes can be identified and recovery of spiked tumor cells is ∼80% [17, 19, 20]....
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...system utilizes immunomagnetic nanoparticles directed against the epithelial cell adhesion molecule (EpCAM) to isolate and concentrate epithelial tumor cells [17, 19]....
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1,977 citations
"Significance of Circulating Tumor C..." refers background in this paper
...In both univariate and multivariate analysis CTC levels at all time points were significantly associated with overall survival [10, 13, 15]....
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