Journal ArticleDOI
Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study.
Lei Kong,Junjie Zhu,Wenxia Han,Xiuyun Jiang,Min Xu,Yue Zhao,Qiongzhu Dong,Zengfen Pang,Qingbo Guan,Ling Gao,Jiajun Zhao,Lei Zhao +11 more
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The expression levels of seven diabetes-relatedMiRNAs in serum were significantly elevated in n-T2D compared with pre-diabetes and/or s-NGT, and the latter two groups featured similar expression patterns of these miRNAs, suggesting that during the pathogenesis of T2D, the peripheral diabetes- related miRNas have not changed significantly from s- NGT at pre- diabetic stage.Abstract:
To explore the clinical significance of seven diabetes-related serum microRNAs (miR-9, miR-29a, miR-30d, miR34a, miR-124a, miR146a and miR375) during the pathogenesis of type 2 diabetes (T2D), 56 subjects were recruited to this study: 18 cases of newly diagnosed T2D (n-T2D) patients, 19 cases of pre-diabetes individuals (impaired glucose tolerance [IGT] and/or impaired fasting glucose [IFG]) and 19 cases of T2D-susceptible individuals with normal glucose tolerance (s-NGT). Serum miRNAs were determined by real-time RT-PCR. Expression levels of single miRNAs and the expression signatures of miRNAs as a panel were analysed among the three groups. In n-T2D, all 7 miRNAs were significantly up-regulated compared with s-NGT and five were significantly up-regulated compared with pre-diabetes, while miRNA expression was not significantly different between s-NGT and pre-diabetes. By Canonical discriminant analysis, 70.6% of n-T2D subjects (12/17) were recognized by canonical discriminant function, while s-NGT and pre-diabetes subjects could not be discriminated from each other. Similar results were found in Hierarchical Clustering analysis based on the expression levels of all seven miRNAs. In different statistical analysis, miR-34a always showed the most significant differences. We conclude that the expression levels of seven diabetes-related miRNAs in serum were significantly elevated in n-T2D compared with pre-diabetes and/or s-NGT, and the latter two groups featured similar expression patterns of these miRNAs, suggesting that during the pathogenesis of T2D, the peripheral diabetes-related miRNAs have not changed significantly from s-NGT at pre-diabetic stage.read more
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Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection : a case control study
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Nonenoy,B. Piyavong,Wisit Prasithsirikul,Phitsanu Raksakulkarn,Brian Gazzard,Jonathan Ainsworth,B. J. Angus,Tristan Barber,M. G. Brook,C. D. Care,David R. Chadwick,M. Chikohora,Duncan Churchill,D. Cornforth,D. H. Dockrell,Philippa Easterbrook,Penny Fox,P. A. Gomez,Mark Gompels,G. M. Harris,Stephen J. Herman,Akil Jackson,S. P.R. Jebakumar,G. R. Kinghorn,K. A. Kuldanek,N. Larbalestier,M. Lumsden,T. Maher,J. Mantell,L. Muromba,Chloe Orkin,S. Peters,Tim E. A. Peto,Simon Portsmouth,S. Rajamanoharan,Ronan,Achim Schwenk,M. A. Slinn,C. J. Stroud,R. C. Thomas,M. H. Wansbrough-Jones,H. J. Whiles,David White,E. Williams,G. Williams,M Youle,Donald I. Abrams,E. A. Acosta,A. Adamski,D. Antoniskis,D. R. Aragon,Ben J. Barnett,C. Baroni,M. Barron,John D. Baxter,D. Beers,M. Beilke,Bemenderfer,A. Bernard,Camille Besch,M. T. Bessesen,J. T. Bethel,S. Blue,J. D. Blum,S. Boarden,Robert K. Bolan,J. B. Borgman,Indira Brar,B. K. Braxton,U. F. Bredeek,R. Brennan,D. E. Britt,D. Bulgin-Coleman,E. Bullock,B. Campbell,S. Caras,J. Carroll,K. K. Casey,F. Chiang,R. B. Cindrich,Cal Cohen,J. Coley,D. V. Condoluci,R. Contreras,J. Corser,J. Cozzolino,Lawrence R. Crane,L. Daley,D. Dandridge,V. D'Antuono,J. G. Darcourt Rizo Patron,J. A. DeHovitz,Edwin DeJesus,J. DesJardin,C. Dietrich,A. Dolce,D. Erickson,L. L. Faber,J. Falbo,M. J. Farrough,Charles Farthing,P. Ferrell-Gonzalez,H. Flynn,M. Frank,K. F. Freeman,N. French,Gerald Friedland,N. Fujita,L. Gahagan,I. Gilson,Matthew Bidwell Goetz,E. Goodwin,C. K. Guity,P. Gulick,E. R. Gunderson,C. M. Hale,K. Hannah,H. Henderson,K. Hennessey,W. K. Henry,T. Higgins,Sally Hodder,H. W. Horowitz,M. Howe-Pittman,J. Hubbard,R. Hudson,H. Hunter,C. Hutelmyer,M. T. Insignares,Lois A. Jackson,L. Jenny,D. L. Johnson,G. Johnson,Jeffrey A. Johnson,J. Kaatz,J. Kaczmarski,S. Kagan,C. Kantor,T. Kempner,K. Kieckhaus,N. Kimmel,B. M. Klaus,J. R. Koeppe,Janak Koirala,J. Kopka,J. R. Kostman,Michael J. Kozal,Ashok Kumar,Harry Lampiris,C. Lamprecht,K. M. Lattanzi,J. Lee,J. Leggett,C. Long,A. Loquere,K. Loveless,C. Lucasti,R. Luskin-Hawk,M. MacVeigh,L. H. Makohon,Norman Markowitz,C. Marks,Claudia Martorell,E. McFeaters,B. McGee,D. M. McIntyre,E. McManus,L. G. Melecio,D. Melton,S. Mercado,E. Merrifield,J. A. Mieras,M. Mogyoros,F. M. Moran,Kellie E. Murphy,S. Mutic,I. Nadeem,J. P. Nadler,A. Ognjan,Mary O'Hearn,K. O'Keefe,P. C. Okhuysen,E. Oldfield,D. Olson,R. Orenstein,Roberto Ortiz,F. Parpart,V. Pastore-Lange,S. Paul,A. Pavlatos,D. D. Pearce,R. Pelz,S. Peterson,D. Pitrak,S. L. Powers,H. C. Pujet,J. W. Raaum,J. Ravishankar,J. Reeder,N. A. Reilly,C. Reyelt,J. Riddell,David Rimland,M. L. Robinson,Allen E. Rodriguez,V. Rodriguez Derouen,C. Rosmarin,W. L. Rossen,J. R. Rouff,M. Sands,C. Savini,Shannon Schrader,M. M. Schulte,R. Scott,H. Seedhom,Michael Sension,A. ShebleHall,Jonathan Shuter,Leonard N. Slater,R. Slotten,Miranda Zoe Denham Smith,S. Snap,D. M. States,G. Stringer,K. K. Summers,K. Swanson,I. B. Sweeton,S. Szabo,Ellen Tedaldi,Edward E. Telzak,Melanie A. Thompson,Sandra C. Thompson,C. Ting Hong Bong,A. Vaccaro,L. M. Vasco,I. Vecino,G. K. Verlinghieri,Fehmida Visnegarwala,H. Wade,Stephen E. Weis,J. A. Weise,S. Weissman,M. Wilkin,J. H. Witter,L. Wojtusic,T. J. Wright,V. Yeh,B. Young,C. Zeana,J. Zeh,E. Savio,M. Vacarezza +1489 more
TL;DR: No associations with mortality were found with any circulating miRNAs studied and these results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection.
Journal ArticleDOI
MicroRNAs in metabolism and metabolic disorders.
Veerle Rottiers,Anders M. Näär +1 more
TL;DR: Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that mi RNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.
Journal ArticleDOI
Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced and inflammatory liver diseases
Shashi Bala,Jan Petrasek,Shiv Mundkur,Donna Catalano,Ivan Levin,Jeanine Ward,Hawau Alao,Karen Kodys,Gyongyi Szabo +8 more
TL;DR: The results suggest that circulating miRNAs may serve as biomarkers to differentiate between hepatocyte injury and inflammation and the exosome versus protein association of mi RNAs may provide further specificity to mechanisms of liver pathology.
Journal ArticleDOI
Circulating microRNAs as novel biomarkers for diabetes mellitus
Claudiane Guay,Romano Regazzi +1 more
TL;DR: In this paper, microRNAs (miRNAs) are used as biomarkers for early detection of the disease and identification of individuals at risk of developing complications, which would greatly improve the care of these patients.
Journal ArticleDOI
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease
TL;DR: The findings that led to these conclusions are reviewed and how this sets the stage for new lines of investigation in which extracellular miRNAs are recognized as important mediators of intercellular communication and potential candidates for therapy of disease.
References
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Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
TL;DR: Findings indicate that the "diabetes epidemic" will continue even if levels of obesity remain constant, and given the increasing prevalence of obesity, it is likely that these figures provide an underestimate of future diabetes prevalence.
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Diagnosis and Classification of Diabetes Mellitus
TL;DR: The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
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Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.
Jaakko Tuomilehto,Jon Lindstrom,Johan G. Eriksson,Valle Tt,Helena Hämäläinen,Pirjo Ilanne-Parikka,Keinänen-Kiukaanniemi S,Mauri Laakso,Anne Louheranta,Rastas M,Salminen,Matti Uusitupa +11 more
TL;DR: Type 2 diabetes can be prevented by changes in the lifestyles of high-risk subjects by means of individualized counseling aimed at reducing weight, total intake of fat, and intake of saturated fat and increasing intake of fiber and physical activity.
Book
Experimental Design and Data Analysis for Biologists
Gerry P. Quinn,Michael J. Keough +1 more
TL;DR: An essential textbook for any student or researcher in biology needing to design experiments, sample programs or analyse the resulting data is as discussed by the authors, covering both classical and Bayesian philosophies, before advancing to the analysis of linear and generalized linear models Topics covered include linear and logistic regression, simple and complex ANOVA models (for factorial, nested, block, split-plot and repeated measures and covariance designs), and log-linear models Multivariate techniques, including classification and ordination, are then introduced.
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