Silencing of microRNAs in vivo with ‘antagomirs’
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Cites background from "Silencing of microRNAs in vivo with..."
...Identities of messages and proteins that increase upon inhibition or removal of an endogenous miRNA demonstrate that nonconserved targeting is even more widespread than conserved targeting (Krutzfeldt et al., 2005; Giraldez et al., 2006; Rodriguez et al., 2007; Baek et al., 2008; Selbach et al., 2008)....
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...Indeed, when endogenous miRNAs are inhibited or removed, most derepressed messages have nonconserved sites (Krutzfeldt et al., 2005; Giraldez et al., 2006; Rodriguez et al., 2007; Baek et al., 2008), raising the possibility that neutral repression might be the most frequent type of biological repression....
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...Subsequent studies inhibiting or ablating endogenous miRNAs conclusively demonstrate the widespread transcriptomic effects on seed-matched messages (Krutzfeldt et al., 2005; Giraldez et al., 2006; Rodriguez et al., 2007)....
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...…of messages and proteins that increase upon inhibition or removal of an endogenous miRNA demonstrate that nonconserved targeting is even more widespread than conserved targeting (Krutzfeldt et al., 2005; Giraldez et al., 2006; Rodriguez et al., 2007; Baek et al., 2008; Selbach et al., 2008)....
[...]
...Indeed, when endogenous miRNAs are inhibited or removed, most derepressed messages have nonconserved sites (Krutzfeldt et al., 2005; Giraldez et al., 2006; Rodriguez et al., 2007; Baek et al., 2008), raising the possibility that neutral repression might be the most frequent type of biological…...
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