Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease.
Alice D. Lam,Gina M. Deck,Alica M. Goldman,Emad N. Eskandar,Jeffrey L. Noebels,Andrew J. Cole +5 more
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The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.Abstract:
We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.read more
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Negative feedback control of neuronal activity by microglia
Ana Badimon,Hayley J. Strasburger,Pinar Ayata,Xinhong Chen,Aditya Nair,Ako Ikegami,Ako Ikegami,Philip Hwang,Andrew T. Chan,Steven M. Graves,Joseph O. Uweru,Carola Ledderose,Munir Gunes Kutlu,Michael A. Wheeler,Anat Kahan,Masago Ishikawa,Ying-Chih Wang,Yong-Hwee E. Loh,Jean X. Jiang,D. James Surmeier,Simon C. Robson,Wolfgang G. Junger,Robert Sebra,Erin S. Calipari,Paul J. Kenny,Ukpong B. Eyo,Marco Colonna,Francisco J. Quintana,Francisco J. Quintana,Hiroaki Wake,Hiroaki Wake,Viviana Gradinaru,Anne Schaefer +32 more
TL;DR: It is suggested that this microglia-driven negative feedback mechanism operates similarly to inhibitory neurons and is essential for protecting the brain from excessive activation in health and disease.
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Mechanically tunable conductive interpenetrating network hydrogels that mimic the elastic moduli of biological tissue.
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Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease
Boaz Styr,Inna Slutsky +1 more
TL;DR: A hypothesis is suggested to explain the transition from ‘silent’ signatures of aberrant neural circuit activity to clinically evident memory impairments and failures in firing homeostasis and imbalance between stability and plasticity represent the driving force of early disease progression.
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Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
Samuel Frere,Inna Slutsky +1 more
TL;DR: It is hypothesized that firing instability and impaired synaptic plasticity at early AD stages trigger a vicious cycle, leading to dysregulation of the whole IHN, and represents the major driving force of the transition from early memory impairments to neurodegeneration.
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Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease
TL;DR: Three publications have now appeared describing data on the development of senile dementia (SD), and the treatment of those with marked overt signs of disease caused by varicella zoster virus (VZV), or by HSV, with striking results show that the risk of SD is much greater in those who are HSV-seropositive than in seronegative subjects, and that antiviral treatment causes a dramatic decrease in number of subjects who later develop SD.
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