Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.
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Cites background from "Silibinin inhibits the invasion of ..."
...Silibinin, a flavonolignan, inhibited invasion and motility of SCC-4 tongue cancer and A459 lung cancer cells by down-regulating MMP-2 and u-PA and upregulating tissue inhibitor of metalloproteinase (TIMP)-2 and PAI-1 expression [216,217]....
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Cites background from "Silibinin inhibits the invasion of ..."
...Moreover, in A549 lung cancer cells, silibinin inhibited MMP-2 and u-PA expression through reducing ERK1/2 and Akt phosphorylation, which in turn led to the reduced invasiveness of the cancer cells [43]....
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...Silibinin at 100 lM concentration inhibited invasion and motility of SCC-4 tongue cancer as well as A459 lung cancer cells by down-regulating MMP-2 and urokinase-type plasminogen activator (u-PA) and up-regulating tissue inhibitor of metalloproteinase2 (TIMP-2) and PAI-1 expressions [42,43]....
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...[43] S....
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References
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"Silibinin inhibits the invasion of ..." refers methods in this paper
...To evaluate the cytotoxicity of silibinin, a MTT colorimetric assay was performed to determine the cell viability [19]....
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"Silibinin inhibits the invasion of ..." refers background in this paper
...For examples, growth factors, cytokines, certain chemicals, or even physical stimulation may promote the expression of MMPs while TGF-b, retinoic acids, glucocortinoids may inhibit [8]....
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1,195 citations
"Silibinin inhibits the invasion of ..." refers background in this paper
...Silibinin, a flavonoid antioxidant, is a major bioactive component present in silymarin which is isolated frommilk thistle (Silybummarianum), and is MOLECULAR CARCINOGENESIS 40:143–149 (2004) 2004 WILEY-LISS, INC. Abbreviations used: ECM, extracellular matrix; MMPs, metalloproteinases; u-PA, urokinase plasminogen activator; TIMP-2, metalloproteinase-2....
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...Therefore, the impacts of silibinin on several proteases involved in ECM degradation were investigated in this study....
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...It has been shown that cell and matrix interactions promote cell migration, proliferation, and ECM degradation [31–33] while inhibitory agents for cell adhesion may reduce the invasiveness and metastatic potential of tumor cells [34,35]....
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...Degradation of ECM by cancer cells via protease, such as serine proteinase, metalloproteinases (MMPs), cathepsins, and plasminogen activator (PA),may lead to the separation of intercellular matrix to promote the mobility of cancer cells and eventually lead to metastasis [1]....
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...Metastasis has been found to be accompanied by various physiological alterations involved in degradation of ECM, which allowed cancer cells to invade blood or lymphatic system to spread to another tissue or organ....
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756 citations