Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.
Chapla Agarwal,Rana P. Singh,Sivanandhan Dhanalakshmi,Anil K. Tyagi,Marianne Tecklenburg,Robert A. Sclafani,Rajesh Agarwal +6 more
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TLDR
The results identify molecular mechanisms of silibinin efficacy as a cell cycle regulator and apoptosis inducer in human colon carcinoma HT-29 cells, and justify further studies to investigate potential usefulness of this nontoxic agent in colon cancer prevention and intervention.Abstract:
Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cellsread more
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Silybin and silymarin - new effects and applications
Vladimir Kren,Daniela Walterová +1 more
TL;DR: This article aims to review critically literature published mainly within this millennium on the new and emerging applications of silymarin, the polyphenolic fraction from the seeds of Silybum marianum and its main component silybin, to suggest new mechanisms of its action.
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Broad targeting of angiogenesis for cancer prevention and therapy
Zongwei Wang,Charlotta Dabrosin,Xin Yin,Mark M. Fuster,Alexandra Arreola,W. Kimryn Rathmell,Daniele Generali,Ganji Purnachandra Nagaraju,Bassel F. El-Rayes,Domenico Ribatti,Yi Charlie Chen,Kanya Honoki,Hiromasa Fujii,Alexandros G. Georgakilas,Somaira Nowsheen,Amedeo Amedei,Elena Niccolai,Amr Amin,S. Salman Ashraf,Bill Helferich,Xujuan Yang,Gunjan Guha,Dipita Bhakta,Maria Rosa Ciriolo,Katia Aquilano,Sophie Chen,Dorota Halicka,Sulma I. Mohammed,Asfar S. Azmi,Alan Bilsland,W. Nicol Keith,Lasse Jensen,Lasse Jensen +32 more
TL;DR: 10 important aspects of tumor angiogenesis and the pathological tumor vasculature which would be well suited as targets for anti-angiogenic therapy are identified and 10 plant-derived compounds could be combined to constitute a broader acting and more effective inhibitory cocktail at doses that would not be likely to cause excessive toxicity.
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Anticancer potential of silymarin: from bench to bed side.
TL;DR: Silymarin is a chemopreventive agent in vivo against a variety of carcinogens/tumor promoters, including UV light, 7,12-dimethylbenz(a)anthracene (DMBA), phorbol 12-myristate 13-acetate (PMA) and others.
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Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin)
TL;DR: The results of this study suggest that these herbal supplements may exert significant and potentially beneficial effects on decreasing the amount of precancerous lesions and inducing apoptosis in the large intestine.
Journal ArticleDOI
Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines: Inhibition of JAK3/STAT3 Signaling Induces Apoptosis and Cell Cycle Arrest of Colon Carcinoma Cells
Quan Lin,Raymond Lai,Lucian R. Chirieac,Changping Li,Vilmos A. Thomazy,Ioannis Grammatikakis,George Z. Rassidakis,Wei Zhang,Yasushi Fujio,Keita Kunisada,Stanley R. Hamilton,Hesham M. Amin +11 more
TL;DR: In this paper, the authors demonstrate that activated STAT3 and activated JAK3 (pSTAT3) are expressed constitutively in two colon cancer cell lines, SW480 and HT29.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Apoptosis in the pathogenesis and treatment of disease
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CDK inhibitors: positive and negative regulators of G1-phase progression
TL;DR: This work challenges previous assumptions about how the G1/S transition of the mammalian cell cycle is governed, helps explain some enigmatic features of cell cycle control that also involve the functions of the retinoblastoma protein (Rb) and the INK4 proteins, and changes the thinking about how either p16 loss or overexpression of cyclin D-dependent kinases contribute to cancer.
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Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
p21 is a universal inhibitor of cyclin kinases
Yue Xiong,Gregory J. Hannon,Gregory J. Hannon,Hui Zhang,Hui Zhang,David J. Casso,David J. Casso,Ryuji Kobayashi,David Beach,David Beach +9 more
TL;DR: It is found that over expression of p21 inhibits the activity of each member of the cyclin/CDK family, and this results indicate that p21 may be a universal inhibitor of cyclin kinases.
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