Single-cell sequencing-based technologies will revolutionize whole-organism science
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..., 2014); and DNA mutations to allow precise reconstruction of cell lineages (Behjati et al., 2014; Biezuner et al., 2016; Shapiro et al., 2013; Taylor et al., 2003; Teixeira et al., 2013)....
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..., 2007; Richmond and Su, 2008), or can be inferred from in vivo samples by measuring the DNA differences between individual sampled cells, arising from random mutations during cell division, and using the genetic distances to construct cellular phylogenies, or lineages (Behjati et al., 2014; Shapiro et al., 2013)....
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...New computational methods will be required both to discover types and to better classify cells and, ultimately, to refine the concepts themselves (Grün and van Oudenaarden, 2015; Shapiro et al., 2013; Stegle et al., 2015; Tanay and Regev, 2017; Wagner et al., 2016)....
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...…and Su, 2008), or can be inferred from in vivo samples by measuring the DNA differences between individual sampled cells, arising from random mutations during cell division, and using the genetic distances to construct cellular phylogenies, or lineages (Behjati et al., 2014; Shapiro et al., 2013)....
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...New computational methods will be required both to discover types and to better classify cells—and ultimately to refine the concepts themselves (Grun and van Oudenaarden, 2015; Shapiro et al., 2013; Stegle et al., 2015; Tanay and Regev, 2017; Wagner et al., 2016)....
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