Single nucleotide polymorphisms within MicroRNAs, MicroRNA targets, and MicroRNA biogenesis genes and their impact on colorectal cancer survival.
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...MiRNAs polymorphisms have been reported to influence the expression of mature miRNAs (13, 14)....
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...MiRNAs are endogenous, single-stranded RNA molecules, approximately 22 nucleotides long that bind to mRNA to repress mRNA translation into protein, or degrade the mRNA molecule (Ambros, 2004; Macfarlane and Murphy, 2010; Murray et al., 2010; Arora et al., 2013)....
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...INTRODUCTION MiRNAs are endogenous, single-stranded RNA molecules, approximately 22 nucleotides long that bind to mRNA to repress mRNA translation into protein, or degrade the mRNA molecule (Ambros, 2004; Macfarlane and Murphy, 2010; Murray et al., 2010; Arora et al., 2013)....
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...MiRNAs undergo three major processing steps to generate the mature miRNA, and this process involves, directly and indirectly, dozens of proteins (Winter et al., 2009; Krol et al., 2010; Ha and Kim, 2014)....
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...Additionally, single nucleotide polymorphisms (SNPs) within miRNA gene regions may alter miRNA transcription and SNPs within miRNA-targets may influence binding of the miRNA to a target, leaving the miRNA unbound within the cytoplasm and vulnerable to degrading nucleases (Krol et al., 2010)....
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...Additionally, single nucleotide polymorphisms (SNPs) within miRNA gene regions may alter miRNA transcription and SNPs within miRNA-targets may influence binding of the miRNA to a target, leaving the miRNA unbound within the cytoplasm and vulnerable to degrading nucleases (Krol et al., 2010)....
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...This gene plays a role in miRNA biogenesis, recruiting ZCCHC11 to the miRNA for uridylation, inhibiting the processing of miRNAs, including the tumor suppressor let-7, by Dicer (Heo et al., 2009; Krol et al., 2010; Stefani et al., 2015)....
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"Single nucleotide polymorphisms wit..." refers background in this paper
...MiRNAs undergo three major processing steps to generate the mature miRNA, and this process involves, directly and indirectly, dozens of proteins (Winter et al., 2009; Krol et al., 2010; Ha and Kim, 2014)....
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