Journal ArticleDOI
Site-specific cleavage of DNA by E. coli DNA gyrase.
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TLDR
Analysis of cleavage fragments showed that cutting between a TG doublet is common to most, or all, gyrase cleavages, and this diverse recognition sequence with common elements is a pattern shared with several other specific nucleic acid-protein interactions.About:
This article is published in Cell.The article was published on 1979-05-01. It has received 181 citations till now. The article focuses on the topics: DNA gyrase & DNA supercoil.read more
Citations
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Journal ArticleDOI
Biochemistry of homologous recombination in Escherichia coli.
TL;DR: This review focuses on the biochemical mechanisms underlying these steps, with particular emphases on the activities of the proteins involved and on the integration of these activities into likely biochemical pathways for recombination.
Journal ArticleDOI
Fluoroquinolone antimicrobial agents.
John S. Wolfson,David C. Hooper +1 more
TL;DR: The fluoroquinolones offer an efficacious, well-tolerated, and cost-effective alternative to parenteral therapies of selected infections and show promise for therapy of prostatitis, respiratory tract infections, osteomyelitis, and cutaneous infections.
Journal ArticleDOI
DNA gyrase and the supercoiling of DNA
TL;DR: Gyrase is a prototype for a growing class of prokaryotic and eukaryotic topoisomerases that interconvert complex forms by way of transient double-strand breaks.
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DNA Gyrase: Structure and Function
Richard J. Reece,Anthony Maxwell +1 more
TL;DR: In this review, the current knowledge concerning DNA gyrase is summarized by addressing a wide range of aspects of the study of this enzyme.
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Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes.
TL;DR: The results strongly suggest that the CcdB protein, like quinolone antibiotics and a variety of antitumoral drugs, is a DNA topoisomerase II poison.
References
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Journal ArticleDOI
Nucleotide sequence of bacteriophage G4 DNA.
TL;DR: The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs.
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Molecular weight estimation and separation of ribonucleic acid by electrophoresis in agarose-acrylamide composite gels
A C Peacock,C W Dingman +1 more
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DNA gyrase: an enzyme that introduces superhelical turns into DNA
TL;DR: Relaxed closed-circular DNA is converted to negatively supercoiled DNA by DNA gyrase by purified from Escherichia coli cells, and the final superhelix density of the DNA can be considerably greater than that found in intracellularly super coiled DNA.
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Complete nucleotide sequence of SV40 DNA
Walter Fiers,Roland Contreras,Guy Haegeman,R. Rogiers,A. Van de Voorde,H. Van Heuverswyn,J. Van Herreweghe,Guido Volckaert,M. Ysebaert +8 more
TL;DR: The determination of the total 5,224 base-pair DNA sequence of the virus SV40 has enabled us to locate precisely the known genes on the genome.
Journal ArticleDOI
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.
TL;DR: Selected regions of cloned EcoRI fragments of the chicken ovalbumin gene have been sequenced, and a previously unreported interruption in the DNA sequences coding for the 5' nontranslated region of the messenger has been discovered.