Journal ArticleDOI
Skin ageing: Skin ageing
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TLDR
The formation of reactive oxygen species and the induction of matrix metalloproteinases reflect the central aspects of skin ageing and the detection of its mechanisms have furthered the development of various therapeutic and preventive strategies.Abstract:
Similar to the entire organism, skin is subject to an unpreventable intrinsic ageing process. Additionally, skin ageing is also influenced by exogenous factors. Ultraviolet radiation in particular results in premature skin ageing, also referred to as extrinsic skin ageing or photoageing, which is the main cause of the changes associated with the ageing process in sun‐exposed areas. Despite their morphological and pathophysiological differences, intrinsic and extrinsic ageing share several molecular similarities. The formation of reactive oxygen species and the induction of matrix metalloproteinases reflect the central aspects of skin ageing. Accumulation of fragmented collagen fibrils prevents neocollagenesis and accounts for the further degradation of the extracellular matrix by means of positive feedback regulation. The importance of extrinsic factors in skin ageing and the detection of its mechanisms have furthered the development of various therapeutic and preventive strategies.read more
Citations
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The extracellular matrix at a glance
TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.
Journal ArticleDOI
Oxidative Stress in Aging Human Skin
TL;DR: In this review the overall effects of oxidative stress are discussed as well as the sources of ROS including the mitochondrial ETC, peroxisomal and ER localized proteins, the Fenton reaction, and such enzymes as cyclooxygenase, lipoxygenases, xanthine oxidases, and NADPH oxidases.
Journal ArticleDOI
Fighting against Skin Aging: The Way from Bench to Bedside.
Shoubing Zhang,Enkui Duan +1 more
TL;DR: This review summarizes changes in skin aging, research advances of the molecular mechanisms leading to these changes, and the treatment strategies aimed at preventing or reversing skin aging.
Journal ArticleDOI
Introduction to skin aging
TL;DR: The topic of human skin aging is introduced, with a focus on how maintenance of function in this complex multi-cell type organ is key for retaining quality of life into old age.
Journal ArticleDOI
Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair
Brett A. Shook,Renee R. Wasko,Guillermo C. Rivera-Gonzalez,Emilio Salazar-Gatzimas,Francesc López-Giráldez,Biraja C. Dash,Andrés R. Muñoz-Rojas,Krystal D. Aultman,Rachel K. Zwick,Vivian Lei,Jack L. Arbiser,Kathryn Miller-Jensen,Damon A. Clark,Henry C. Hsia,Valerie Horsley +14 more
TL;DR: Variation in healing and scarring rates in multiple tissues suggests that fibroblast diversity exists, and functionally distinct subsets of myofibroblast subsets in skin wound beds from adult mice are defined.
References
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Oxidative Stress, Caloric Restriction, and Aging
TL;DR: Support for this hypothesis includes the following observations: (i) Overexpression of antioxidative enzymes retards the age-related accrual of oxidative damage and extends the maximum life-span of transgenic Drosophila melanogaster and (ii) Variations in longevity among different species inversely correlate with the rates of mitochondrial generation of the superoxide anion radical and hydrogen peroxide.
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Mechanisms of photoaging and chronological skin aging
Gary J. Fisher,Sewon Kang,James Varani,Zsuzsanna Bata-Csorgo,Yinsheng Wan,Subhash C. Datta,John J. Voorhees +6 more
TL;DR: This article reviews the current understanding and presents new data about the molecular pathways that mediate skin damage by UV irradiation and by the passage of time and reveals that chronological aging and photoaging share fundamental molecular pathways.
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Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Gary J. Fisher,Subhash C. Datta,Harvinder S. Talwar,Zeng Quan Wang,James Varani,Sewon Kang,John J. Voorhees +6 more
TL;DR: It is proposed that elevated metalloprotein-ases, resulting from activation of AP-1 and NF-KB by low-dose solar irradiation, degrade collagen and elastin in skin, which would result in solar scars, which through accumulation from a lifetime of repeated low- dose sunlight exposure could cause premature skin ageing (photoageing).