Sleep disturbances in patients with schizophrenia : impact and effect of antipsychotics.
Citations
36 citations
Cites background from "Sleep disturbances in patients with..."
...Disturbed sleep is estimated to occur in 30–80 % of people with schizophrenia, depending on the degree of psychotic symptomatology (Cohrs 2008)....
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35 citations
Cites background from "Sleep disturbances in patients with..."
...Selective serotonin-reuptake inhibitors (SSRI) and the serotonin-norepinephrine-reuptake inhibitors (SNRI) have alerting effects, and are linked to fragmented sleep, increased SOL and daytime somnolence (DeMartinis and Winokur, 2007)....
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...For instance, studies show that both typical and atypical antipsychotics have beneficial effects on sleep patterns by increasing sleep efficiency and total sleep time, and reducing sleep onset latency (SOL) (DeMartinis and Winokur, 2007; Cohrs, 2008; Winokur and Kamath, 2008)....
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35 citations
Cites background from "Sleep disturbances in patients with..."
...Instead, the co-morbidity of schizophrenia and SCRDmay reflect dysfunction in common brain mechanisms, such as the glutamate system, which is clearly relevant to sleep [23–25], photic entrainment [14–16] and schizophrenia [12, 13]....
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...The prevalence of SCRD in schizophrenia has been attributed to the use of antipsychotic medication and the absence of social routine [10, 11], but, contrary to these explanations, SCRD is seen in both medication-naïve patients [11] and patients that follow a fixed daily routine [7]....
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...The co-morbidity of schizophrenia and SCRDmay in part stem from dysfunction in common brain mechanisms, which include the glutamate system, and in particular, the group II metabotro- pic glutamate receptors mGlu2 andmGlu3 (encoded by the genesGrm2 andGrm3)....
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...Schizophrenia is a debilitating psychiatric disorder that affects 0.3–0.7% of the world’s population [1], while sleep and/or circadian rhythm disruption (SCRD) is observed in 30–80% of schizophrenia patients [2]....
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...Group II metabotropic glutamate receptors could be relevant to SCRD in neuropsychiatric disorders besides schizophrenia....
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34 citations
Cites background from "Sleep disturbances in patients with..."
...Up to 80% of patients with schizophrenia experience insomnia-related symptoms, including an inability to fall or stay asleep, or daytime somnolence (Cohrs, 2008)....
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34 citations
Cites background from "Sleep disturbances in patients with..."
...Consequently, benzodiazepines potentially aggravate the disrupted sleep pattern identified in mentally ill patients (Monti and Monti, 2004; Abad and Guilleminault, 2005; Cohrs, 2008)....
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References
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