Sleep disturbances in patients with schizophrenia : impact and effect of antipsychotics.
Citations
99 citations
Cites background from "Sleep disturbances in patients with..."
...Crucially, patients with SCRD score badly on many quality-of-life clinical sub- scales, highlighting the human cost of SCRD in schizo- phrenia (Cohrs 2008; Goldman et al. 1996; Hofstetter et al. 2005)....
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...More specifically, schizophrenia patients treated with typical antipsychotics show an increase in their sleep efficiency and total sleep time (Cohrs 2008)....
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...Recent data would suggest that, if anything, antipsychotic drug treatment can actually improve sleep quality in schizophrenia (Cohrs 2008; Krystal et al. 2008)....
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...More specifically, schizophrenia patients treated with typical antipsychotics show an increase in their sleep efficiency and total sleep time (Cohrs 2008)....
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...Today, sleep and circadian rhythm dis- ruption (SCRD) is reported in 30–80 % of patients with schizophrenia, and is increasingly recognised as one of the most common features of the disorder (Cohrs 2008)....
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99 citations
95 citations
Cites background from "Sleep disturbances in patients with..."
...…REM sleep abnormalities are listed as one of the prominent endophenotypes of depression and other diseases (see Hasler et al., 2004; Fleming, 1994; Cohrs, 2008; Germain and Nielsen, 2003) manifesting as short REM latency, elevated REM density (increased eye movements during REM sleep), and…...
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...For instance, REM sleep abnormalities are listed as one of the prominent endophenotypes of depression and other diseases (see Hasler et al., 2004; Fleming, 1994; Cohrs, 2008; Germain and Nielsen, 2003) manifesting as short REM latency, elevated REM density (increased eye movements during REM sleep), and prolongation of the first REM period, as well as reduced total sleep time, sleep efficiency especially....
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94 citations
Cites background from "Sleep disturbances in patients with..."
...Atypical antipsychotics tend to improve sleep induction and/or sleep maintenance in SZ patients (Monti and Monti, 2004), and most atypical antipsychotics demonstrate an increase in total sleep time and/or sleep efficiency in SZ patients,with the exception of risperidone (Cohrs, 2008)....
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...Patients with schizophrenia (SZ) frequently experience sleep problems (Keshavan et al., 1990; Taylor et al., 1991; Tandon et al., 1992;Monti andMonti, 2004; Cohrs, 2008), like advanced sleep phase syndrome and hypersomnia with short naps (Wirz-Justice et al., 2001)....
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...However, because of the limited number of methodologically rigorous studies, no clear statement can be made about the influence of these variables on sleep structure (Cohrs, 2008)....
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...This suggests that sleep physiology might share a common substrate with SZ symptoms (Boivin, 2000; Poulin et al., 2003; Cohrs, 2008)....
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...To disentangle the effects of schizophrenia itself from the influence of medication on sleep is difficult (Cohrs, 2008), but it seems unlikely that treatment only could explain the differences between the groups....
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