Journal ArticleDOI
Small protein-protein interfaces rich in electrostatic are often linked to regulatory function.
Christina Nilofer,Anshul Sukhwal,Arumugam Mohanapriya,Meena Kishore Sakharkar,Pandjassarame Kangueane +4 more
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TLDR
It is interesting to observe that complexes having small interfaces are often associated with regulatory function, and large interfaces have two-fold more interface area and interface size than small interfaces with increasing hydrogen bonding energy to interface size.Abstract:
Protein–protein interaction (PPI) is critical for several biological functions in living cells through the formation of an interface. Therefore, it is of interest to characterize protein–protein in...read more
Citations
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Prediction of Protein–Protein Interaction Sites Based on Stratified Attentional Mechanisms
TL;DR: Wang et al. as discussed by the authors proposed a Hierarchical Attention Network (HANPPIS) to predict protein-protein interaction sites, which added six effective features of protein sequence feature, position-specific scoring matrix (PSSM), secondary structure feature, pre-training vector feature, hydrophilic feature and amino acid position feature.
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From Anna University to America and to Agriculture.
TL;DR: Anna University (AU) is an awesome alma mater for attracting the attention of the invincible through awareness from education, it is a place with a plan for preparing a palace in a person's life and an avenue for America through adequate cGPA and Advanced GRE with good TOEFL score.
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Insights from the interfaces of HIV-1 envelope (ENV) trimer viral protein GP160 (GP120-GP41)
TL;DR: The previous finding stating that small protein-protein interfaces rich in electrostatics holds true in case of GP41 whereas not with GP120 protein interfaces holds true.
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In silico analysis of protein-protein interfaces: Tools and approaches
TL;DR: This review enumerates the different interface features reported thus far along with the tools that aid in deciphering protein features (physicochemical characteristics, binding site and interface residue prediction and hotspot residues) along with their approaches that are employed in the prediction these features.
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Electrostatic Interactions Contribute to the Overall Structural Stability in Small Interfaces of Corona Viral Spike Glycoproteins
TL;DR: Information on heteromeric interactions of glycoproteins may help develop new and productive therapeutic drugs and is found to be absent at the small interfaces having subdominant vdW energy.
References
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B. Lee,Frederic M. Richards +1 more
TL;DR: The accessibility of atoms in the twenty common amino acids in model tripeptides of the type Ala-X-Ala are given for defined conformation and the larger non-polar amino acids tend to be more “buried” in the native form of all three proteins.
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Principles of protein-protein interactions
Susan Jones,Janet M. Thornton +1 more
TL;DR: This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition.
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The atomic structure of protein-protein recognition sites.
TL;DR: In this paper, the authors performed an analysis of the recognition sites seen in 75 protein-protein complexes of known three-dimensional structure: 24 protease-inhibitor, 19 antibody-antigen and 32 other complexes, including nine enzymeinhibitors and 11 that are involved in signal transduction.
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Principles of protein–protein recognition
Cyrus Chothia,Joël Janin +1 more
TL;DR: Results indicate that hydrophobicity is the major factor stabilising protein–protein association, while complementarity plays a selective role in deciding which proteins may associate.
Journal ArticleDOI
The structure of protein-protein recognition sites.
Joël Janin,Cyrus Chothia +1 more