Smoking, p53 Mutation, and Lung Cancer
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Cites background from "Smoking, p53 Mutation, and Lung Can..."
...Because cigarette exposure leads to increased TMB which might cause enhanced the sensitivity to immunotherapy, it is necessary to rule out the interference from cigarette exposure [112]....
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385 citations
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Cites background from "Smoking, p53 Mutation, and Lung Can..."
...Exploring new compounds that target mutant p53 and restore its wild-type function are potential therapeutic strategies for cancers, especially NSCLC, due to the high mutation rate of p53 [55,93,94]....
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References
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"Smoking, p53 Mutation, and Lung Can..." refers methods in this paper
...The second generation of animal models that were created relied upon gene targeting to produce a null p53 allele, which could then be studied in heterozygous or homozygous conditions (54)....
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"Smoking, p53 Mutation, and Lung Can..." refers background in this paper
...Nutlin (RG7112) was the first compound described in its class, capable of targeting the interaction of p53 and MDM2 (95)....
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...The TP53 gene encodes for a protein of 53 kDa, which is a sequence-specific transcription factor found at low levels under normal cellular conditions due to the regulatory action of the E3 ubiquitin ligase mouse double minute 2 (MDM2) (28, 29)....
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...By blocking the p53 binding cleft of MDM2, nutlins inhibit MDM2-mediated degradation of WT p53, increasing p53 transcriptional activity....
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3,665 citations