SMRT Derepression by the IκB Kinase α: A Prerequisite to NF-κB Transcription and Survival
Reads0
Chats0
TLDR
In this paper, the authors demonstrate that NF-κB transcription requires IKKα to phosphorylate SMRT on chromatin, stimulating the exchange of corepressor for coactivator complexes.About:
This article is published in Molecular Cell.The article was published on 2004-10-22 and is currently open access. It has received 221 citations till now. The article focuses on the topics: Derepression & Corepressor.read more
Citations
More filters
Journal ArticleDOI
Integrating cell-signalling pathways with NF-kappaB and IKK function.
TL;DR: This work has shown that crosstalk constitutes a decision-making process that determines the consequences of NF-κB and IKK activation and, ultimately, cell fate.
Journal ArticleDOI
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.
Gabriel Pascual,Amy L. Fong,Sumito Ogawa,Amir Gamliel,Andrew C. Li,Valentina Perissi,David W. Rose,Timothy M. Willson,Michael G. Rosenfeld,Christopher K. Glass +9 more
TL;DR: This mechanism provides an explanation for how an agonist-bound nuclear receptor can be converted from an activator of transcription to a promoter-specific repressor of NF-κB target genes that regulate immunity and homeostasis.
Journal ArticleDOI
New regulators of NF-kappaB in inflammation.
Sankar Ghosh,Matthew S. Hayden +1 more
TL;DR: This Review discusses new insights into the regulation of NF-κB, a key mediator of inducible transcription in the immune system, that have been identified and some of the known components have been assigned new roles.
Journal ArticleDOI
Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response.
TL;DR: This strategy imposes a temporal order for modifying programs of transcriptional regulation in response to the cellular milieu, which is used to mediate developmental/homeostatic and pathological events.
Journal ArticleDOI
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway
TL;DR: Understanding these pathways will not only provide valuable insights into mechanism and function, but could also lead to new drug targets and the development of diagnostic and prognostic biomarkers for many pathological conditions.
References
More filters
Journal ArticleDOI
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
TL;DR: The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
Journal ArticleDOI
Missing Pieces in the NF-κB Puzzle
Sankar Ghosh,Michael Karin +1 more
TL;DR: In this paper, a review of recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK is presented, focusing on recent progress and unanswered questions.
Journal ArticleDOI
NF-κB at the crossroads of life and death
Michael Karin,Anning Lin +1 more
TL;DR: The choice between life and death is one of the major events in regulation of the immune system and a major regulator of such life or death decisions is the transcription factor NF-κB as mentioned in this paper.
Journal ArticleDOI
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
Fan Yeung,Jamie E. Hoberg,Catherine S. Ramsey,Michael D Keller,David R. Jones,Roy A. Frye,Marty W. Mayo +6 more
TL;DR: It is demonstrated that SIRT1, a nicotinamide adenosine dinucleotide‐dependent histone deacetylase, regulates the transcriptional activity of NF‐κB and activity augments apoptosis in response to TNFα.
Journal ArticleDOI
The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior
TL;DR: The Myc/Max/Mad network comprises a group of transcription factors whose distinct interactions result in gene-specific transcriptional activation or repression and can be viewed as a functional module which acts to convert environmental signals into specific gene-regulatory programs.
Related Papers (5)
Transcriptional co-repressor that interacts with nuclear hormone receptors
Ronald M. Evans,J. Don Chen +1 more