Journal ArticleDOI
Social defeat stress affects resident's clock gene and bdnf expression in the brain.
Simona Moravcová,Kateřina Červená,Hana Míková,Dominika Pačesová,Gergely Pallag,Jiří Novotný,Zdeňka Bendová +6 more
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TLDR
The data suggest that the model of stress-induced anxiety and depression should consider a group of residents because, for some parameters, they may respond more distinctively than intruders, and the utility of an experimental group ofResidents could be contributive.Abstract:
Social defeat stress affects behavior and changes the expression of the genes underlying neuronal plasticity in the brain. The circadian clock regulates most neuronal processes in the brain, which results in daily variations of complex behavior, and any disturbance in circadian clock oscillations increases the risk of mood and cognitive disbalance. In this study, we assessed the effect of acute and repeated social defeat stress on Per2 and Nr1d1 expression in prefrontal cortexes, hippocampi, pineal glands, olfactory bulbs, cerebella, and pituitary glands. We also evaluated the effect of our experimental setting on levels of Bdnf and plasma corticosterone, two markers widely used to asses the impact of stress on mammalian physiology. Our data show that single and repeated social defeat stress upregulates the expression of both clock genes and Bdnf in all brain structures, and corticosterone in the blood. While the general pattern of Bdnf upregulation suggests higher sensitivity in the intruder group, the clock genes are induced more significantly in residents, especially by repeated stress sessions. Our work thus suggests that the model of stress-induced anxiety and depression should consider a group of residents because, for some parameters, they may respond more distinctively than intruders.LAY SUMMARYThe resident/intruder experimental paradigm affects the expression of clock genes Per2, Nr1d1and Bdnf in the brain structures and plasma corticosterone level. The induction of clock genes is evident in both experimental groups; however, it is more marked in residents. Together with the significant increase in Bdnf levels in the majority of brain structures and plasma corticosterone in residents, our data suggest that in the model of social defeat stress, the utility of an experimental group of residents could be contributive.read more
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Early Life Stress Alters Gene Expression and Cytoarchitecture in the Prefrontal Cortex Leading to Social Impairment and Increased Anxiety.
Usui Noriyoshi,Yuta Ono,Ryoko Aramaki,Stefano Berto,Genevieve Konopka,Hideo Matsuzaki,Shoichi Shimada +6 more
TL;DR: In this article, the authors performed social isolation on weaned pre-adolescent mice until adolescence and investigated these behaviors and PFC characteristics in adolescent mice and found that early life stress (ELS) induced social impairments in social novelty, social interaction, and social preference.
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Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress.
Salvatore G. Caradonna,Tie-Yuan Zhang,Nicholas O’Toole,Mojun Shen,Huzefa Khalil,Nathan R. Einhorn,Xianglan Wen,Carine Parent,Francis S. Lee,Huda Akil,Michael J. Meaney,Bruce S. McEwen,Jordan Marrocco +12 more
TL;DR: In this article, the authors investigated the genomic signatures in the ventral hippocampus common to mouse models of stress using RNA-sequencing and found that differentially expressed genes (DEGs) were concordant for gene networks involved in neurotransmission, cytoskeleton function, and vascularization.
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Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules.
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Inconsistent effects of sleep deprivation on memory function.
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Evolution of stress responses refine mechanisms of social rank
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References
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Journal ArticleDOI
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,Colleen A. McClung,Ralph J. DiLeone,Vaishnav Krishnan,William Renthal,Scott J. Russo,Danielle Graham,Nadia M. Tsankova,Carlos A. Bolaños,Maribel Rios,Lisa M. Monteggia,David W. Self,Eric J. Nestler,Eric J. Nestler +13 more
TL;DR: It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
Journal ArticleDOI
Mania-like behavior induced by disruption of CLOCK.
Kole T. Roybal,David Theobold,Ami Graham,Jennifer A. DiNieri,Scott J. Russo,Vaishnav Krishnan,Sumana Chakravarty,Joseph Peevey,Nathan Oehrlein,Shari G. Birnbaum,Martha Hotz Vitaterna,Paul Orsulak,Joseph S. Takahashi,Eric J. Nestler,William A. Carlezon,Colleen A. McClung +15 more
TL;DR: It is shown that mice carrying a mutation in the Clock gene display an overall behavioral profile that is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower anxiety, and an increase in the reward value for cocaine, sucrose, and medial forebrain bundle stimulation.
Journal ArticleDOI
Timing to Perfection: The Biology of Central and Peripheral Circadian Clocks
TL;DR: This review will highlight the relationship between clocks and metabolism, and describe how cues such as light, food, and reward mediate entrainment of the circadian system.
Journal ArticleDOI
Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress.
TL;DR: It is suggested that social defeat stress alters ERK1/2, IL-6, GLO1, GSR1, CAMKIV, CREB, and BDNF levels in specific brain areas, leading to oxidative stress-induced anxiety-depression-like behaviors and as well as memory impairment in rats.
Journal ArticleDOI
Dendritic Spines in Depression: What We Learned from Animal Models
TL;DR: Current understanding of the chronic stress-induced remodeling of dendritic spines in the hippocampus, prefrontal cortex, orbitofrontal cortex, amygdala, and nucleus accumbens is summarized and the putative underlying mechanisms are discussed.
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