Journal ArticleDOI
Social isolation in mice: behavior, immunity, and tumor growth.
Dan Farbstein,Nurit Hollander,Orit Peled,Alan Apter,Silvana Fennig,Yael Haberman,Hila Gitman,Isaac Yaniv,Vered Shkalim,Chaim G. Pick,Noa Benaroya-Milshtein +10 more
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TLDR
Results show that social isolation leads to changes in the Hypothalamic-hypophyseal-adrenal axis, which in turn alter the response to stress, and social isolation was shown to impact tumor progression.Abstract:
The aim of this study was to investigate the behavioral, immunological, and neurological effects of long-term isolation in an animal model. Male C3H/eB mice wereraised in either social isolation or...read more
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Animal Models of Depression: What Can They Teach Us about the Human Disease?
TL;DR: In this paper, a review of the most common tests used for the evaluation of depressive-like symptoms in rodents is presented, and the authors describe different models of depression and discuss their strengths and weaknesses, including genetic models, models induced by mental acute and chronic stressful situations caused by environmental manipulations, and drugs induced by pharmacological tools.
Journal ArticleDOI
The Role of Immune Cells in Oxi-Inflamm-Aging
TL;DR: In this article, the function of immune cells can be used as an indicator of the rate of aging of an individual, and the immune system can work as a driver of aging by amplifying the oxidative-inflammatory stress associated with aging (oxi-inflamm-aging).
Journal ArticleDOI
Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged mice.
Izabelle Dias Benfato,Ana Carolina Silvares Quintanilha,Jessica Salles Henrique,Melyssa Alves Souza,Barbara dos Anjos Rosário,Jose Ivo Araújo Beserra Filho,Robson Luiz Oliveira Santos,Alessandra Mussi Ribeiro,Luciana Le Sueur Maluf,Camila Aparecida Machado de Oliveira +9 more
TL;DR: In this paper, the effects of long-term social isolation on metabolic, behavioural, and central nervous system-related areas in middle-aged mice were investigated, and it was shown that chronic social isolation contributes to alterations in feeding, physical activity pattern, and anxiety-like behaviour.
Journal ArticleDOI
Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged mice
TL;DR: In this paper , the effects of long-term social isolation on metabolic, behavioural, and central nervous system-related areas in middle-aged mice were investigated, and it was shown that chronic social isolation contributes to alterations in feeding, physical activity pattern, and anxiety-like behaviour.
Journal ArticleDOI
Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression
Olga Abramova,Yana Zorkina,Timur Syunyakov,E. A. Zubkov,Valeria Ushakova,Artemiy S. Silantyev,Kristina Soloveva,Olga I. Gurina,Alexander G. Majouga,Anna Morozova,Vladimir P. Chekhonin +10 more
TL;DR: In this paper, the brain metabolome after antidepressant therapy is poorly understood and had not been performed for different routes of drug administration before the present study, and the brain metabolites in the frontal cortex and hippocampus were analyzed with liquid chromatography.
References
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Effects of stress on immune function: the good, the bad, and the beautiful.
TL;DR: It is proposed that short-term stress is one of the nature’s fundamental but under-appreciated survival mechanisms that could be clinically harnessed to enhance immunoprotection and “good” versus “bad” effects of stress on health.
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Psychoneuroendocrine influences on immunocompetence and neoplasia
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Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection and immunopathology.
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Post-traumatic stress disorder: the neurobiological impact of psychological trauma.
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Journal ArticleDOI
Environmental enrichment in mice decreases anxiety, attenuates stress responses and enhances natural killer cell activity.
Noa Benaroya-Milshtein,Nurit Hollander,Alan Apter,Tova Kukulansky,Nava Raz,A. Wilf,Isaac Yaniv,Chaim G. Pick +7 more
TL;DR: EE has a beneficial effect on anxiety‐like behaviour, stress response andNK cell activity, and the effect on NK cell activity is promising, due to the role of NK cells in host resistance.
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