# Soft Computing in Bioinformatics

01 Jan 2021-pp 431-446

TL;DR: In this paper, the authors explored the soft computing based techniques for bioinformatics and discussed the necessity of soft computing techniques and their compatibility for solving wide spectrum of bio-informatic related problems.

Abstract: In this chapter, we explored the soft computing based techniques for bioinformatics. Necessity of soft computing techniques and their compatibility for solving wide spectrum of bioinformatics related problems is reviewed. Basics of soft computing techniques are discussed and their relevancy in solving many bioinformatics based problems is also elaborated. Actual experimental results on two real world bioinformatics data demonstrated the efficacy of soft computing techniques over conventional one for biological data problems.

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06 Aug 2002

TL;DR: A concept for the optimization of nonlinear functions using particle swarm methodology is introduced, and the evolution of several paradigms is outlined, and an implementation of one of the paradigm is discussed.

Abstract: A concept for the optimization of nonlinear functions using particle swarm methodology is introduced. The evolution of several paradigms is outlined, and an implementation of one of the paradigms is discussed. Benchmark testing of the paradigm is described, and applications, including nonlinear function optimization and neural network training, are proposed. The relationships between particle swarm optimization and both artificial life and genetic algorithms are described.

35,104 citations

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TL;DR: In this article, it is shown that many particular choices among possible neurophysiological assumptions are equivalent, in the sense that for every net behaving under one assumption, there exists another net which behaves under another and gives the same results, although perhaps not in the same time.

14,937 citations

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01 Jan 2001

TL;DR: This text provides an excellent introduction to the use of evolutionary algorithms in multi-objective optimization, allowing use as a graduate course text or for self-study.

Abstract: From the Publisher:
Evolutionary algorithms are relatively new, but very powerful techniques used to find solutions to many real-world search and optimization problems. Many of these problems have multiple objectives, which leads to the need to obtain a set of optimal solutions, known as effective solutions. It has been found that using evolutionary algorithms is a highly effective way of finding multiple effective solutions in a single simulation run. · Comprehensive coverage of this growing area of research · Carefully introduces each algorithm with examples and in-depth discussion · Includes many applications to real-world problems, including engineering design and scheduling · Includes discussion of advanced topics and future research · Features exercises and solutions, enabling use as a course text or for self-study · Accessible to those with limited knowledge of classical multi-objective optimization and evolutionary algorithms The integrated presentation of theory, algorithms and examples will benefit those working and researching in the areas of optimization, optimal design and evolutionary computing. This text provides an excellent introduction to the use of evolutionary algorithms in multi-objective optimization, allowing use as a graduate course text or for self-study.

12,134 citations

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01 Aug 1996

TL;DR: A simple case in point is the problem of parking a car as discussed by the authors, where the final position of the car is not specified exactly, and if it were specified to within, say, a few millimeters and a fraction of a degree, it would take hours or days of maneuvering and precise measurements of distance and angular position.

Abstract: The past few years have witnessed a rapid growth of interest in a cluster of modes of modeling and computation which may be described collectively as soft computing. The distinguishing characteristic of soft computing is that its primary aims are to achieve tractability, robustness, low cost, and high MIQ (machine intelligence quotient) through an exploitation of the tolerance for imprecision and uncertainty. Thus, in soft computing what is usually sought is an approximate solution to a precisely formulated problem or, more typically, an approximate solution to an imprecisely formulated problem. A simple case in point is the problem of parking a car. Generally, humans can park a car rather easily because the final position of the car is not specified exactly. If it were specified to within, say, a few millimeters and a fraction of a degree, it would take hours or days of maneuvering and precise measurements of distance and angular position to solve the problem. What this simple example points to is the fact that, in general, high precision carries a high cost. The challenge, then, is to exploit the tolerance for imprecision by devising methods of computation which lead to an acceptable solution at low cost. By its nature, soft computing is much closer to human reasoning than the traditional modes of computation. At this juncture, the major components of soft computing are fuzzy logic (FL), neural network theory (NN), and probabilistic reasoning techniques (PR), including genetic algorithms, chaos theory, and part of learning theory. Increasingly, these techniques are used in combination to achieve significant improvement in performance and adaptability. Among the important application areas for soft computing are control systems, expert systems, data compression techniques, image processing, and decision support systems. It may be argued that it is soft computing, rather than the traditional hard computing, that should be viewed as the foundation for artificial intelligence. In the years ahead, this may well become a widely held position.

1,483 citations

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TL;DR: Today, the authors have microwave ovens and washing machines that can figure out on their own what settings to use to perform their tasks optimally; cameras that come close to professional photographers in picture-taking ability; and many other products that manifest an impressive capability to reason, make intelligent decisions, and learn from experience.

Abstract: Prof. Zadeh presented a comprehensive lecture on fuzzy logic, neural networks, and soft computing. In addition, he lead a spirited discussion of how these relatively new techniques may be applied to safety evaluation of time variant and nonlinear structures based on identification approaches. The abstract of his lecture is given as follows.

1,390 citations