Solid Dispersions as Strategy to Improve Oral Bioavailability of Poor Water Soluble Drugs
Citations
1,201 citations
Cites background from "Solid Dispersions as Strategy to Im..."
...Second-generation polymeric carriers—including PVP, PEG, polymethacrylates, and HPMC (and its derivatives) —and 3rd-generation carriers including self-emulsifying and surfactant-based excipients are now considerably more common (Serajuddin, 1999; Vasconcelos et al., 2007)....
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399 citations
Cites background or methods from "Solid Dispersions as Strategy to Im..."
...Riegelman [9] as well as the review by Vasconcelos et al [7]....
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...Two phase blends (sometimes termed solid suspensions), on the other hand, occurwhen thedrughas limitedmiscibility in the carrier and undergoes phase separation [7,9]....
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...For a more comprehensive descriptions of these various types of systems, the readers are encouraged to read the classic review of Chiou and Riegelman [9] as well as the review by Vasconcelos et al [7]....
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...formation [5], and complexation [6], rendering the drug amorphous is an attractive option [7]....
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370 citations
Cites background from "Solid Dispersions as Strategy to Im..."
...…amorphous drugs (Janssens and Van den Mooter, 2009). morphous drug–polymer mixtures are often hygroscopic and in hat case the absorbed moisture reduces the Tg of the system, leadng to phase separation and recrystallization (Lu and Zografi, 1998; asconcelos et al., 2007; Rumondor and Taylor, 2010)....
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336 citations
319 citations
Cites background from "Solid Dispersions as Strategy to Im..."
...Among the many strategies attempted are prodrugs (1, 2), salt formation (3–5), crystal engineering (6–8), solid dispersions (9, 10), and micellar systems (11)....
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References
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