Solid Lipid Based Nano-particulate Formulations in Drug Targeting
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In this chapter, this chapter has discussed about the SLNs and their different surface modified forms for passive as well as active targeting to different organ such as (colon, breast, lungs, liver, kidney, brain, eyes, etc.) in combating different diseases.Abstract:
Recently, targeted drug delivery systems have gained much more interest for delivering varieties of drugs as well as imaging agents specifically to the targeted disease cells or tissues. These are well known for their increased precision and accuracy in mode of drug delivery along with reduced side effects. Though numerous carriers are being employed for drug targeting, the solid lipid based nanoparticles (SLNs) are preferred over them owing to their ability to encapsulate wide varieties of drugs, biocompatibility, ease of surface modification, scaling up feasibility, and possibilities of both active as well as passive targeting to various organs. Surface of these drug loaded SLNs can be modified by conjugating different ligands to enhance their tissue/organ targeting ability and therapeutic efficacy to much higher extent. In this chapter, we have discussed about the SLNs and their different surface modified forms for passive as well as active targeting to different organ such as (colon, breast, lungs, liver, kidney, brain, eyes, etc.) in combating different diseases.read more
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Book ChapterDOI
Novel Controlled Release Pulmonary Drug Delivery Systems: Current updates and Challenges
Daljeet Singh Dhanjal,Meenu Mehta,Meenu Mehta,Chirag Chopra,Reena Singh,Parvarish Sharma,Dinesh Kumar Chellappan,Murtaza M. Tambuwala,Hamid A. Bakshi,Alaa A. A. Aljabali,Gaurav Gupta,Srinivas Nammi,Parteek Prasher,Kamal Dua,Kamal Dua,Saurabh Satija,Saurabh Satija +16 more
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The role of lipid based nanoparticles in brain targeted drug delivery system: An overview
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References
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Journal ArticleDOI
Nanoparticle-based targeted drug delivery
TL;DR: This article presents an overview of nanotechnology for the biologist and discusses the attributes of the novel XPclad((c)) nanoparticle formulation that has shown efficacy in treating solid tumors, single dose vaccination, and oral delivery of therapeutic proteins.
Journal ArticleDOI
Lipid-based nanoparticles for nucleic acid delivery
TL;DR: This paper focuses on the formulation/assembly of lipid-based nanoparticles (NP) with diameter under 100 nm for delivering nucleic acid in vivo, and examines the major formulation factors that impact the diameter and encapsulation efficiency of DNA-containing NP.
Journal ArticleDOI
Enhanced rifampicin delivery to alveolar macrophages by solid lipid nanoparticles
TL;DR: In vivo delivery efficiency and the selectivity of RFP-SLNs were further verified in Sprague–Dawley rats and demonstrated that solid lipid nanoparticles are a promising strategy for the delivery of rifampicin to alveolar macrophages selectively.
Journal ArticleDOI
Nanomedicine in pulmonary delivery.
TL;DR: This review focuses on the current status and explores the potential of colloidal carriers (ie, nanocarrier systems) in pulmonary drug delivery with special attention to their pharmaceutical aspects.
Journal ArticleDOI
Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier
Carine Fillebeen,Laurence Descamps,Marie-Pierre Dehouck,Laurence Fenart,Monique Benaïssa,Geneviève Spik,Roméo Cecchelli,Roméo Cecchelli,Annick Pierce +8 more
TL;DR: It is shown that iron may cross the bovine brain capillary endothelial cells as a complex with Lf and that the low density lipoprotein receptor-related protein might be involved in this process because its specific antagonist, the receptor-associated protein, inhibits 70% of Lf transport.